Wolff-parkinson-white syndrome in the era of catheter ablation insights from a registry study of 2169 patients

Carlo Pappone, Gabriele Vicedomini, Francesco Manguso, Massimo Saviano, Mario Baldi, Alessia Pappone, Cristiano Ciaccio, Luigi Giannell, Bogdan Ionescu, Andrea Petretta, Raffaele Vitale, Amarild Cuko, Zarko Calovic, Angelica Fundaliotis, Mario Moscatiello, Luigi Tavazzi, Vincenzo Santinelli

Research output: Contribution to journalArticlepeer-review


Background :The management of Wolff-Parkinson-White is based on the distinction between asymptomatic and symptomatic presentations, but evidence is limited in the asymptomatic population. Methods and Results: The Wolff-Parkinson-White registry was an 8-year prospective study of either symptomatic or asymptomatic Wolff-Parkinson-White patients referred to our Arrhythmology Department for evaluation or ablation. Inclusion criteria were a baseline electrophysiological testing with or without radiofrequency catheter ablation (RFA). Primary end points were the percentage of patients who experienced ventricular fibrillation (VF) or potentially malignant arrhythmias and risk factors. Among 2169 enrolled patients, 1001 (550 asymptomatic) did not undergo RFA (no-RFA group) and 1168 (206 asymptomatic) underwent ablation (RFA group). There were no differences inclinical and electrophysiological characteristics between the 2 groups except for symptoms. In the no-RFA group, VF occurred in 1.5% of patients, virtually exclusively (13 of 15) in children (median age, 11 years), and was associated with a short accessory pathway antegrade refractory period (P

Original languageEnglish
Pages (from-to)811-819
Number of pages9
Issue number10
Publication statusPublished - Sep 2 2014


  • Death
  • Sudden
  • Ventricular fibrillation
  • Wolff-Parkinson-White syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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