Wolfram's syndrome: A clinical, diagnostic, and interpretative contribution

C. Blasi, F. Pierelli, E. Rispoli, M. Saponara, E. Vingolo, D. Andreani

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Four cases (belonging to two different families) of Wolfram's syndrome (WS), a rare congenital disease characterized in its complete form by insulin-dependent diabetes mellitus, optic atrophy, diabetes insipidus, deafness, and dilation of the urinary tracts are presented, and a review of the literature is included. Three of four patients are characterized by HLA-DR2 haplotype, which is rare in IDDM. The neurodegenerative nature of some symptoms and the possible pathogenesis of diabetes mellitus connected with it are discussed.

Original languageEnglish
Pages (from-to)521-528
Number of pages8
JournalDiabetes Care
Volume9
Issue number5
Publication statusPublished - 1986

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Wolfram Syndrome
Type 1 Diabetes Mellitus
HLA-DR2 Antigen
Optic Atrophy
Diabetes Insipidus
Deafness
Rare Diseases
Urinary Tract
Haplotypes
Dilatation
Diabetes Mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Blasi, C., Pierelli, F., Rispoli, E., Saponara, M., Vingolo, E., & Andreani, D. (1986). Wolfram's syndrome: A clinical, diagnostic, and interpretative contribution. Diabetes Care, 9(5), 521-528.

Wolfram's syndrome : A clinical, diagnostic, and interpretative contribution. / Blasi, C.; Pierelli, F.; Rispoli, E.; Saponara, M.; Vingolo, E.; Andreani, D.

In: Diabetes Care, Vol. 9, No. 5, 1986, p. 521-528.

Research output: Contribution to journalArticle

Blasi, C, Pierelli, F, Rispoli, E, Saponara, M, Vingolo, E & Andreani, D 1986, 'Wolfram's syndrome: A clinical, diagnostic, and interpretative contribution', Diabetes Care, vol. 9, no. 5, pp. 521-528.
Blasi C, Pierelli F, Rispoli E, Saponara M, Vingolo E, Andreani D. Wolfram's syndrome: A clinical, diagnostic, and interpretative contribution. Diabetes Care. 1986;9(5):521-528.
Blasi, C. ; Pierelli, F. ; Rispoli, E. ; Saponara, M. ; Vingolo, E. ; Andreani, D. / Wolfram's syndrome : A clinical, diagnostic, and interpretative contribution. In: Diabetes Care. 1986 ; Vol. 9, No. 5. pp. 521-528.
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