Won't you come on in?: How to favor lymphocyte infiltration in tumors

Matteo Bellone; Arianna Calcinotto; Angelo Corti

doi:10.4161/onci.20213

Won't you come on in? How to favor lymphocyte infiltration in tumors

Matteo Bellone, Arianna Calcinotto, Angelo Corti

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Abnormal tumor vasculature and endothelial cell anergy limit tumor/T-cell interactions. We have found that NGR-TNF, a tumor vasculature-homing derivative of TNF, selectively activates endothelial cells in neoplastic tissues and induces the release of chemokines that favor tumor infiltration by T cells, thereby enhancing the efficacy of active and adoptive immunotherapy.

Original language	English
Pages (from-to)	986-988
Number of pages	3
Journal	OncoImmunology
Volume	1
Issue number	6
DOIs	https://doi.org/10.4161/onci.20213
Publication status	Published - 2012

Keywords

Cell trafficking
Endothelial cells
Immunotherapy
T cells
Tumor

ASJC Scopus subject areas

Immunology and Allergy
Oncology
Immunology

Access to Document

10.4161/onci.20213

Cite this

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abstract = "Abnormal tumor vasculature and endothelial cell anergy limit tumor/T-cell interactions. We have found that NGR-TNF, a tumor vasculature-homing derivative of TNF, selectively activates endothelial cells in neoplastic tissues and induces the release of chemokines that favor tumor infiltration by T cells, thereby enhancing the efficacy of active and adoptive immunotherapy.",

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