Abstract
Abnormal tumor vasculature and endothelial cell anergy limit tumor/T-cell interactions. We have found that NGR-TNF, a tumor vasculature-homing derivative of TNF, selectively activates endothelial cells in neoplastic tissues and induces the release of chemokines that favor tumor infiltration by T cells, thereby enhancing the efficacy of active and adoptive immunotherapy.
Original language | English |
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Pages (from-to) | 986-988 |
Number of pages | 3 |
Journal | OncoImmunology |
Volume | 1 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- Cell trafficking
- Endothelial cells
- Immunotherapy
- T cells
- Tumor
ASJC Scopus subject areas
- Immunology and Allergy
- Oncology
- Immunology