Won't you come on in? How to favor lymphocyte infiltration in tumors

Matteo Bellone, Arianna Calcinotto, Angelo Corti

Research output: Contribution to journalArticlepeer-review

Abstract

Abnormal tumor vasculature and endothelial cell anergy limit tumor/T-cell interactions. We have found that NGR-TNF, a tumor vasculature-homing derivative of TNF, selectively activates endothelial cells in neoplastic tissues and induces the release of chemokines that favor tumor infiltration by T cells, thereby enhancing the efficacy of active and adoptive immunotherapy.

Original languageEnglish
Pages (from-to)986-988
Number of pages3
JournalOncoImmunology
Volume1
Issue number6
DOIs
Publication statusPublished - 2012

Keywords

  • Cell trafficking
  • Endothelial cells
  • Immunotherapy
  • T cells
  • Tumor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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