Work-rate affects cardiopulmonary exercise test results in heart failure

Piergiuseppe Agostoni, Michele Bianchi, Andrea Moraschi, Pietro Palermo, Gaia Cattadori, Rocco La Gioia, Maurizio Bussotti, Karlman Wasserman

Research output: Contribution to journalArticlepeer-review


Aims: Cardiopulmonary exercise test (CPET) is used to evaluate patients with chronic heart failure (HF) usually by means of a personalized ramp exercise protocol. Our aim was to evaluate if exercise duration or ramp rate influences the results. Methods and results: Ninety HF patients were studied (peak V̇O2: >20 ml/min/kg, n=28, 15-20 ml/min/kg, n=39 and O2 averaged 16.9±4.3*, 18.0±4.4 and 18.0±5.4 ml/min/kg for the 5-, 10- and 15-min tests, (*=pO2 and heart rate were lowest in 5-min tests regardless of HF severity. The ΔV̇O2/Δwork-rate was lowest in 5-min tests and highest in 15-min tests. At all ramp rates, ΔV̇O2/ Δwork-rate was lower for the subjects with the lower peak V̇O2. The V̇e/V̇CO2 slope and V̇O2 at anaerobic threshold were not affected by the protocol for any grade of HF. Conclusions: In chronic HF, exercise protocol has a small effect on peak V̇O2 and ΔV̇O2/Δwork but does not affect V̇O2 at anaerobic threshold and V̇e/V̇CO2 slope.

Original languageEnglish
Pages (from-to)498-504
Number of pages7
JournalEuropean Journal of Heart Failure
Issue number4
Publication statusPublished - Jun 2005


  • Exercise
  • Heart failure
  • Oxygen consumption

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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