World federation of societies of biological psychiatry guidelines for the pharmacological treatment of dementias in primary care

Ralf Ihl; Robertas Bunevicius; Lutz Frölich; Bengt Winblad; Lon S. Schneider; Bruno Dubois; Alistair Burns; Florence Thibaut; Siegfried Kasper; Hans Jürgen Möller; Wioletta Baranska-Rybak; Wieclaw J. Cubala; Jaanus Harro; Victor J M Pop; Elmars Rancans; Jill Rasmussen; Zoltan Rihmer; Djea Saravane; Thomas E. Schlaepfer; Leo Sher; S. W. Tang; Leonas Valius; David Wong; Larisa M. Zhitnikova; Joseph Zohar; Michel Benoit; Rafael Blesa; Henry Brodaty; Nancy Colimon; Islwan Degrell; Steve DeKosky; Engin Eker; Hidetoshi Endo; Timo Erkinjuntti; Hans Förstl; Giovanni Frisoni; Serge Gauthier; Ezio Giacobini; Teresa Gomez-Isla; Carl Gerhard Goufries; Michael Grundman; Changsu Han; Christoph Hock; Isin Baral Kulaksizoglu; Josef Marksteiner; Colin Masters; Ian McKeith; Maria Olofsdottir; Michael Rainer; Barry Reisberg; Peter Riederer; Martin Rossor; Bernd Saletu; Eric Salmon; Trey Sunderland; Masatoshi Takeda; Bilgen Taneli; Bruno Vellas; Frans Verhey; Gunhild Waldemar; Peter Whitehouse

doi:10.3109/13651501.2014.961931

World federation of societies of biological psychiatry guidelines for the pharmacological treatment of dementias in primary care

Ralf Ihl, Robertas Bunevicius, Lutz Frölich, Bengt Winblad, Lon S. Schneider, Bruno Dubois, Alistair Burns, Florence Thibaut, Siegfried Kasper, Hans Jürgen Möller, Wioletta Baranska-Rybak, Wieclaw J. Cubala, Jaanus Harro, Victor J M Pop, Elmars Rancans, Jill Rasmussen, Zoltan Rihmer, Djea Saravane, Thomas E. Schlaepfer, Leo SherS. W. Tang, Leonas Valius, David Wong, Larisa M. Zhitnikova, Joseph Zohar, Michel Benoit, Rafael Blesa, Henry Brodaty, Nancy Colimon, Islwan Degrell, Steve DeKosky, Engin Eker, Hidetoshi Endo, Timo Erkinjuntti, Hans Förstl, Giovanni Frisoni, Serge Gauthier, Ezio Giacobini, Teresa Gomez-Isla, Carl Gerhard Goufries, Michael Grundman, Changsu Han, Christoph Hock, Isin Baral Kulaksizoglu, Josef Marksteiner, Colin Masters, Ian McKeith, Maria Olofsdottir, Michael Rainer, Barry Reisberg, Peter Riederer, Martin Rossor, Bernd Saletu, Eric Salmon, Trey Sunderland, Masatoshi Takeda, Bilgen Taneli, Bruno Vellas, Frans Verhey, Gunhild Waldemar, Peter Whitehouse

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Review article › peer-review

Abstract

Objective. To define a practice guideline for biological treatment of dementias for general practitioners in primary care. Methods. TThis paper is a short and practical summary of the World Federation of Biological Psychiatry (WFSBP) guidelines for the Biological treatment of Alzheimer's disease and other dementias for treatment in primary care (Ihl et al. 2011). The recommendations were developed by a task force of international experts in the field and arc based on randomized controlled studies. Results. Anti-dementia medications neither cure, nor arrest, or alter the course of the disease. The type of dementia, the individual symptom constellation and the tolerability and evidence for efficacy should determine what medications should be used. In treating neuropsychiatrie symptoms, psychosocial intervention should be the treatment of first choice. For neuropsychiatrie symptoms, medications should only be considered when psychosocial interventions are not adequate and after cautious risk-benefit analysis. Conclusions. Depending on the diagnostic entity and clinical presentation different anti-dementia drugs can be recommended. These guidelines provide a practical approach for general practitioners managing dementias.

Original language	English
Pages (from-to)	2-7
Number of pages	6
Journal	International Journal of Psychiatry in Clinical Practice
Volume	19
Issue number	1
DOIs	https://doi.org/10.3109/13651501.2014.961931
Publication status	Published - Mar 1 2015

Keywords

Alzheimer's disease
Anti-dementia drugs
Dementia
Guidelines
Lewy body disease
Neuropsychiatric symptoms

ASJC Scopus subject areas

Psychiatry and Mental health
Medicine(all)

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Ihl, R., Bunevicius, R., Frölich, L., Winblad, B., Schneider, L. S., Dubois, B., Burns, A., Thibaut, F., Kasper, S., Möller, H. J., Baranska-Rybak, W., Cubala, W. J., Harro, J., Pop, V. J. M., Rancans, E., Rasmussen, J., Rihmer, Z., Saravane, D., Schlaepfer, T. E., ... Whitehouse, P. (2015). World federation of societies of biological psychiatry guidelines for the pharmacological treatment of dementias in primary care. International Journal of Psychiatry in Clinical Practice, 19(1), 2-7. https://doi.org/10.3109/13651501.2014.961931

World federation of societies of biological psychiatry guidelines for the pharmacological treatment of dementias in primary care. / Ihl, Ralf; Bunevicius, Robertas; Frölich, Lutz; Winblad, Bengt; Schneider, Lon S.; Dubois, Bruno; Burns, Alistair; Thibaut, Florence; Kasper, Siegfried; Möller, Hans Jürgen; Baranska-Rybak, Wioletta; Cubala, Wieclaw J.; Harro, Jaanus; Pop, Victor J M; Rancans, Elmars; Rasmussen, Jill; Rihmer, Zoltan; Saravane, Djea; Schlaepfer, Thomas E.; Sher, Leo; Tang, S. W.; Valius, Leonas; Wong, David; Zhitnikova, Larisa M.; Zohar, Joseph; Benoit, Michel; Blesa, Rafael; Brodaty, Henry; Colimon, Nancy; Degrell, Islwan; DeKosky, Steve; Eker, Engin; Endo, Hidetoshi; Erkinjuntti, Timo; Förstl, Hans; Frisoni, Giovanni; Gauthier, Serge; Giacobini, Ezio; Gomez-Isla, Teresa; Goufries, Carl Gerhard; Grundman, Michael; Han, Changsu; Hock, Christoph; Kulaksizoglu, Isin Baral; Marksteiner, Josef; Masters, Colin; McKeith, Ian; Olofsdottir, Maria; Rainer, Michael; Reisberg, Barry; Riederer, Peter; Rossor, Martin; Saletu, Bernd; Salmon, Eric; Sunderland, Trey; Takeda, Masatoshi; Taneli, Bilgen; Vellas, Bruno; Verhey, Frans; Waldemar, Gunhild; Whitehouse, Peter.

In: International Journal of Psychiatry in Clinical Practice, Vol. 19, No. 1, 01.03.2015, p. 2-7.

Research output: Contribution to journal › Review article › peer-review

Ihl, R, Bunevicius, R, Frölich, L, Winblad, B, Schneider, LS, Dubois, B, Burns, A, Thibaut, F, Kasper, S, Möller, HJ, Baranska-Rybak, W, Cubala, WJ, Harro, J, Pop, VJM, Rancans, E, Rasmussen, J, Rihmer, Z, Saravane, D, Schlaepfer, TE, Sher, L, Tang, SW, Valius, L, Wong, D, Zhitnikova, LM, Zohar, J, Benoit, M, Blesa, R, Brodaty, H, Colimon, N, Degrell, I, DeKosky, S, Eker, E, Endo, H, Erkinjuntti, T, Förstl, H, Frisoni, G, Gauthier, S, Giacobini, E, Gomez-Isla, T, Goufries, CG, Grundman, M, Han, C, Hock, C, Kulaksizoglu, IB, Marksteiner, J, Masters, C, McKeith, I, Olofsdottir, M, Rainer, M, Reisberg, B, Riederer, P, Rossor, M, Saletu, B, Salmon, E, Sunderland, T, Takeda, M, Taneli, B, Vellas, B, Verhey, F, Waldemar, G & Whitehouse, P 2015, 'World federation of societies of biological psychiatry guidelines for the pharmacological treatment of dementias in primary care', International Journal of Psychiatry in Clinical Practice, vol. 19, no. 1, pp. 2-7. https://doi.org/10.3109/13651501.2014.961931

Ihl, Ralf ; Bunevicius, Robertas ; Frölich, Lutz ; Winblad, Bengt ; Schneider, Lon S. ; Dubois, Bruno ; Burns, Alistair ; Thibaut, Florence ; Kasper, Siegfried ; Möller, Hans Jürgen ; Baranska-Rybak, Wioletta ; Cubala, Wieclaw J. ; Harro, Jaanus ; Pop, Victor J M ; Rancans, Elmars ; Rasmussen, Jill ; Rihmer, Zoltan ; Saravane, Djea ; Schlaepfer, Thomas E. ; Sher, Leo ; Tang, S. W. ; Valius, Leonas ; Wong, David ; Zhitnikova, Larisa M. ; Zohar, Joseph ; Benoit, Michel ; Blesa, Rafael ; Brodaty, Henry ; Colimon, Nancy ; Degrell, Islwan ; DeKosky, Steve ; Eker, Engin ; Endo, Hidetoshi ; Erkinjuntti, Timo ; Förstl, Hans ; Frisoni, Giovanni ; Gauthier, Serge ; Giacobini, Ezio ; Gomez-Isla, Teresa ; Goufries, Carl Gerhard ; Grundman, Michael ; Han, Changsu ; Hock, Christoph ; Kulaksizoglu, Isin Baral ; Marksteiner, Josef ; Masters, Colin ; McKeith, Ian ; Olofsdottir, Maria ; Rainer, Michael ; Reisberg, Barry ; Riederer, Peter ; Rossor, Martin ; Saletu, Bernd ; Salmon, Eric ; Sunderland, Trey ; Takeda, Masatoshi ; Taneli, Bilgen ; Vellas, Bruno ; Verhey, Frans ; Waldemar, Gunhild ; Whitehouse, Peter. / World federation of societies of biological psychiatry guidelines for the pharmacological treatment of dementias in primary care. In: International Journal of Psychiatry in Clinical Practice. 2015 ; Vol. 19, No. 1. pp. 2-7.

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abstract = "Objective. To define a practice guideline for biological treatment of dementias for general practitioners in primary care. Methods. TThis paper is a short and practical summary of the World Federation of Biological Psychiatry (WFSBP) guidelines for the Biological treatment of Alzheimer's disease and other dementias for treatment in primary care (Ihl et al. 2011). The recommendations were developed by a task force of international experts in the field and arc based on randomized controlled studies. Results. Anti-dementia medications neither cure, nor arrest, or alter the course of the disease. The type of dementia, the individual symptom constellation and the tolerability and evidence for efficacy should determine what medications should be used. In treating neuropsychiatrie symptoms, psychosocial intervention should be the treatment of first choice. For neuropsychiatrie symptoms, medications should only be considered when psychosocial interventions are not adequate and after cautious risk-benefit analysis. Conclusions. Depending on the diagnostic entity and clinical presentation different anti-dementia drugs can be recommended. These guidelines provide a practical approach for general practitioners managing dementias.",

keywords = "Alzheimer's disease, Anti-dementia drugs, Dementia, Guidelines, Lewy body disease, Neuropsychiatric symptoms",

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AU - Ihl, Ralf

AU - Bunevicius, Robertas

AU - Frölich, Lutz

AU - Winblad, Bengt

AU - Schneider, Lon S.

AU - Dubois, Bruno

AU - Burns, Alistair

AU - Thibaut, Florence

AU - Kasper, Siegfried

AU - Möller, Hans Jürgen

AU - Baranska-Rybak, Wioletta

AU - Cubala, Wieclaw J.

AU - Harro, Jaanus

AU - Pop, Victor J M

AU - Rancans, Elmars

AU - Rasmussen, Jill

AU - Rihmer, Zoltan

AU - Saravane, Djea

AU - Schlaepfer, Thomas E.

AU - Sher, Leo

AU - Tang, S. W.

AU - Valius, Leonas

AU - Wong, David

AU - Zhitnikova, Larisa M.

AU - Zohar, Joseph

AU - Benoit, Michel

AU - Blesa, Rafael

AU - Brodaty, Henry

AU - Colimon, Nancy

AU - Degrell, Islwan

AU - DeKosky, Steve

AU - Eker, Engin

AU - Endo, Hidetoshi

AU - Erkinjuntti, Timo

AU - Förstl, Hans

AU - Frisoni, Giovanni

AU - Gauthier, Serge

AU - Giacobini, Ezio

AU - Gomez-Isla, Teresa

AU - Goufries, Carl Gerhard

AU - Grundman, Michael

AU - Han, Changsu

AU - Hock, Christoph

AU - Kulaksizoglu, Isin Baral

AU - Marksteiner, Josef

AU - Masters, Colin

AU - McKeith, Ian

AU - Olofsdottir, Maria

AU - Rainer, Michael

AU - Reisberg, Barry

AU - Riederer, Peter

AU - Rossor, Martin

AU - Saletu, Bernd

AU - Salmon, Eric

AU - Sunderland, Trey

AU - Takeda, Masatoshi

AU - Taneli, Bilgen

AU - Vellas, Bruno

AU - Verhey, Frans

AU - Waldemar, Gunhild

AU - Whitehouse, Peter

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AB - Objective. To define a practice guideline for biological treatment of dementias for general practitioners in primary care. Methods. TThis paper is a short and practical summary of the World Federation of Biological Psychiatry (WFSBP) guidelines for the Biological treatment of Alzheimer's disease and other dementias for treatment in primary care (Ihl et al. 2011). The recommendations were developed by a task force of international experts in the field and arc based on randomized controlled studies. Results. Anti-dementia medications neither cure, nor arrest, or alter the course of the disease. The type of dementia, the individual symptom constellation and the tolerability and evidence for efficacy should determine what medications should be used. In treating neuropsychiatrie symptoms, psychosocial intervention should be the treatment of first choice. For neuropsychiatrie symptoms, medications should only be considered when psychosocial interventions are not adequate and after cautious risk-benefit analysis. Conclusions. Depending on the diagnostic entity and clinical presentation different anti-dementia drugs can be recommended. These guidelines provide a practical approach for general practitioners managing dementias.

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KW - Dementia

KW - Guidelines

KW - Lewy body disease

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World federation of societies of biological psychiatry guidelines for the pharmacological treatment of dementias in primary care

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