Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)

M. Matz, M.P. Coleman, H. Carreira, D. Salmerón, M.D. Chirlaque, C. Allemani, S. Bouzbid, M. Hamdi-Chérif, Z. Zaidi, E. Bah, R. Swaminathan, S.H. Nortje, M.M. El Mistiri, S. Bayo, B. Malle, S.S. Manraj, R. Sewpaul-Sungkur, A. Fabowale, O.J. Ogunbiyi, D. BradshawN.I.M. Somdyala, D.C. Stefan, M. Abdel-Rahman, L. Jaidane, M. Mokni, I. Kumcher, F. Moreno, M.S. González, E.A. Laura, S.B. Espinola, G.H. Calabrano, B. Carballo Quintero, R. Fita, D.A. Garcilazo, P.L. Giacciani, M.C. Diumenjo, W.D. Laspada, M.A. Green, M.F. Lanza, S.G. Ibañez, C.A. Lima, E. Lobo de Oliveira, C. Daniel, C. Scandiuzzi, P.C.F. De Souza, C.D. Melo, K. Del Pino, C. Laporte, M.P. Curado, J.C. de Oliveira, C.L.A. Veneziano, D.B. Veneziano, M.R.D.O. Latorre, L.F. Tanaka, G. Azevedo e Silva, J.C. Galaz, J.A. Moya, D.A. Herrmann, S. Vargas, V.M. Herrera, C.J. Uribe, L.E. Bravo, N.E. Arias-Ortiz, D.M. Jurado, M.C. Yépez, Y.H. Galán, P. Torres, F. Martínez-Reyes, M.L. Pérez-Meza, L. Jaramillo, R. Quinto, P. Cueva, J.G. Yépez, C.R. Torres-Cintrón, G. Tortolero-Luna, R. Alonso, E. Barrios, C. Nikiforuk, L. Shack, A.J. Coldman, R.R. Woods, G. Noonan, D. Turner, E. Kumar, B. Zhang, F.R. McCrate, S. Ryan, H. Hannah, R.A.D. Dewar, M. MacIntyre, A. Lalany, M. Ruta, L. Marrett, D.E. Nishri, C. McClure, K.A. Vriends, C. Bertrand, R. Louchini, K.I. Robb, H. Stuart-Panko, S. Demers, S. Wright, J.T. George, X. Shen, J.T. Brockhouse, D.K. O'Brien, K.C. Ward, L. Almon, J. Bates, R. Rycroft, L. Mueller, C. Phillips, H. Brown, B. Cromartie, A.G. Schwartz, F. Vigneau, J.A. MacKinnon, B. Wohler, A.R. Bayakly, C.A. Clarke, S.L. Glaser, D. West, M.D. Green, B.Y. Hernandez, C.J. Johnson, D. Jozwik, M.E. Charlton, C.F. Lynch, B. Huang, T.C. Tucker, D. Deapen, L. Liu, M.C. Hsieh, X.C. Wu, K. Stern, S.T. Gershman, R.C. Knowlton, J. Alverson, G.E. Copeland, D.B. Rogers, D. Lemons, L.L. Williamson, M. Hood, G.M. Hosain, J.R. Rees, K.S. Pawlish, A. Stroup, C. Key, C. Wiggins, A.R. Kahn, M.J. Schymura, G. Leung, C. Rao, L. 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Matsuda, O. Nimri, A. Ab Manan, N. Bhoo-Pathy, S. Tuvshingerel, O. Chimedsuren, A.H.M. Al Khater, H. Al-Eid, K.W. Jung, Y.J. Won, C.J. Chiang, M.S. Lai, K. Suwanrungruang, S. Wiangnon, K. Daoprasert, D. Pongnikorn, S.L. Geater, H. Sriplung, S. Eser, C.I. Yakut, M. Hackl, H. Mühlböck, W. Oberaigner, A.A. Zborovskaya, O.V. Aleinikova, K. Henau, L. Van Eycken, N. Dimitrova, Z. Valerianova, M. Šekerija, M. Zvolský, G. Engholm, H. Storm, K. Innos, M. Mägi, N. Malila, K. Seppä, J. Jégu, M. Velten, E. Cornet, X. Troussard, A.M. Bouvier, J. Faivre, A.V. Guizard, V. Bouvier, G. Launoy, P. Arveux, M. Maynadié, M. Mounier, E. Fournier, A.S. Woronoff, M. Daoulas, J. Clavel, S. Le Guyader-Peyrou, A. Monnereau, B. Trétarre, M. Colonna, A. Cowppli-Bony, F. Molinié, S. Bara, D. Degré, O. Ganry, B. Lapôtre-Ledoux, P. Grosclaude, J. Estève, F. Bray, M. Piñeros, F. Sassi, R. Stabenow, A. Eberle, C. Erb, A. Nennecke, J. Kieschke, E. Sirri, H. Kajueter, K. Emrich, S.R. Zeissig, B. Holleczek, N. 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Dyzmann-Sroka, M. Trojanowski, S. Góźdż, R. Mężyk, M. Grądalska-Lampart, A.U. Radziszewska, J.A. Didkowska, U. Wojciechowska, J. Błaszczyk, K. Kępska, M. Bielska-Lasota, K. Kwiatkowska, G. Forjaz, R.A. Rego, J. Bastos, M.A. Silva, L. Antunes, M.J. Bento, A. Mayer-da-Silva, A. Miranda, D. Coza, A.I. Todescu, M.Y. Valkov, J. Adamcik, C. Safaei Diba, M. Primic-Žakelj, T. Žagar, J. Stare, E. Almar, A. Mateos, J.R. Quirós, J. Bidaurrazaga, N. Larrañaga, J.M. Díaz García, A.I. Marcos, R. Marcos-Gragera, M.L. Vilardell Gil, E. Molina, M.J. Sánchez, P. Franch Sureda, M. Ramos Montserrat, C. Navarro, E.E. Ardanaz, C.C. Moreno-Iribas, R. Fernández-Delgado, R. Peris-Bonet, J. Galceran, S. Khan, M. Lambe, B. Camey, C. Bouchardy, M. Usel, S.M. Ess, C. Herrmann, J.L. Bulliard, M. Maspoli-Conconi, H. Frick, C.E. Kuehni, M. Schindler, A. Bordoni, A. Spitale, A. Chiolero, I. Konzelmann, S.I. Dehler, K.L. Matthes, J. Rashbass, C.A. Stiller, D. Fitzpatrick, A. Gavin, F. Bannon, R.J. Black, D.H. Brewster, D.W. Huws, C. White, P. Finan, A. Bonaventure, V. Di Carlo, R. Harewood, K. Liu, L. Montel, M. Nikšić, B. Rachet, N. Sanz, D. Spika, R. Stephens, M. Peake, E. Chalker, L. Newman, D. Baker, M.J. Soeberg, J. Aitken, C. Scott, B.C. Stokes, A. Venn, H. Farrugia, G.G. Giles, T. Threlfall, D. Currow, H. You, J. Hendrix, C. Lewis

Research output: Contribution to journalArticlepeer-review

Abstract

Objective Ovarian cancer comprises several histological groups with widely differing levels of survival. We aimed to explore international variation in survival for each group to help interpret international differences in survival from all ovarian cancers combined. We also examined differences in stage-specific survival. Methods The CONCORD programme is the largest population-based study of global trends in cancer survival, including data from 60 countries for 695,932 women (aged 15–99 years) diagnosed with ovarian cancer during 1995–2009. We defined six histological groups: type I epithelial, type II epithelial, germ cell, sex cord-stromal, other specific non-epithelial and non-specific morphology, and estimated age-standardised 5-year net survival for each country by histological group. We also analysed data from 67 cancer registries for 233,659 women diagnosed from 2001 to 2009, for whom information on stage at diagnosis was available. We estimated age-standardised 5-year net survival by stage at diagnosis (localised or advanced). Results Survival from type I epithelial ovarian tumours for women diagnosed during 2005–09 ranged from 40 to 70%. Survival from type II epithelial tumours was much lower (20–45%). Survival from germ cell tumours was higher than that of type II epithelial tumours, but also varied widely between countries. Survival for sex-cord stromal tumours was higher than for the five other groups. Survival from localised tumours was much higher than for advanced disease (80% vs. 30%). Conclusions There is wide variation in survival between histological groups, and stage at diagnosis remains an important factor in ovarian cancer survival. International comparisons of ovarian cancer survival should incorporate histology. © 2016 Elsevier Inc.
Original languageEnglish
Pages (from-to)396-404
Number of pages9
JournalGynecologic Oncology
Volume144
Issue number2
DOIs
Publication statusPublished - 2017

Keywords

  • epidemiology
  • histology
  • morphology
  • ovarian cancer
  • stage
  • survival
  • adolescent
  • adult
  • advanced cancer
  • aged
  • Article
  • Brenner tumor
  • cancer localization
  • cancer registry
  • cancer staging
  • cancer survival
  • clear cell carcinoma
  • colloid carcinoma
  • comparative study
  • controlled study
  • endometrioid carcinoma
  • epithelium tumor
  • female
  • geographic distribution
  • germ cell tumor
  • groups by age
  • human
  • human tissue
  • mixed tumor
  • ovary cancer
  • priority journal
  • sex cord tumor
  • squamous cell carcinoma
  • survival time
  • transitional cell carcinoma
  • trend study
  • undifferentiated carcinoma
  • middle aged
  • mortality
  • ovary tumor
  • pathology
  • very elderly
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Staging
  • Ovarian Neoplasms

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