Worldwide epidemiology and antibiotic resistance of Staphylococcus aureus

Monica Monaco, Fernanda Pimentel de Araujo, Melania Cruciani, Eliana M. Coccia, Annalisa Pantosti

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Staphylococcus aureus is an important human pathogen, responsible for infections in the community and the healthcare setting. Although much of the attention is focused on the methicillin-resistant “variant” MRSA, the methicillin-susceptible counterpart (MSSA) remains a prime species in infections. The epidemiology of S. aureus, especially of MRSA, showed a rapid evolution in the last years. After representing a typical nosocomial multidrug-resistant pathogen, MRSA has recently emerged in the community and among farmed animals thanks to its ability to evolve and adapt to different settings. Global surveillance has shown that MRSA represents a problem in all continents and countries where studies have been carried out, determining an increase in mortality and the need to use last-resource expensive antibiotics. S. aureus can easily acquire resistance to antibiotics and MRSA is characteristically multidrug resistant. Resistance to vancomycin, the principal anti-MRSA antibiotic is rare, although isolates with decreased susceptibility are recovered in many areas. Resistance to the more recently introduced antibiotics, linezolid and daptomycin, has emerged; however, they remain substantially active against the large majority of MSSA and MRSA. Newer antistaphylococcal drugs have been developed, but since their clinical use has been very limited so far, little is known about the emergence of resistance. Molecular typing techniques have allowed to identify the major successful clones and lineages of MSSA and MRSA, including high-risk clones, and to trace their diffusion. In the face of a continuously evolving scenario, this review depicts the most common clones circulating in different geographical areas and in different settings at present. Since the evolution of S. aureus will continue, it is important to maintain the attention on the epidemiology of S. aureus in the future with a global view.

Original languageEnglish
Title of host publicationCurrent Topics in Microbiology and Immunology
PublisherSpringer Verlag
Pages21-56
Number of pages36
DOIs
Publication statusPublished - Jan 1 2017

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume409
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965

Fingerprint

Methicillin-Resistant Staphylococcus aureus
Microbial Drug Resistance
Staphylococcus aureus
Epidemiology
Methicillin
Linezolid
Clone Cells
Anti-Bacterial Agents
Vancomycin Resistance
Daptomycin
Molecular Typing
Community Health Services
Methicillin Resistance
Infection
Mortality
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Monaco, M., Pimentel de Araujo, F., Cruciani, M., Coccia, E. M., & Pantosti, A. (2017). Worldwide epidemiology and antibiotic resistance of Staphylococcus aureus. In Current Topics in Microbiology and Immunology (pp. 21-56). (Current Topics in Microbiology and Immunology; Vol. 409). Springer Verlag. https://doi.org/10.1007/82_2016_3

Worldwide epidemiology and antibiotic resistance of Staphylococcus aureus. / Monaco, Monica; Pimentel de Araujo, Fernanda; Cruciani, Melania; Coccia, Eliana M.; Pantosti, Annalisa.

Current Topics in Microbiology and Immunology. Springer Verlag, 2017. p. 21-56 (Current Topics in Microbiology and Immunology; Vol. 409).

Research output: Chapter in Book/Report/Conference proceedingChapter

Monaco, M, Pimentel de Araujo, F, Cruciani, M, Coccia, EM & Pantosti, A 2017, Worldwide epidemiology and antibiotic resistance of Staphylococcus aureus. in Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol. 409, Springer Verlag, pp. 21-56. https://doi.org/10.1007/82_2016_3
Monaco M, Pimentel de Araujo F, Cruciani M, Coccia EM, Pantosti A. Worldwide epidemiology and antibiotic resistance of Staphylococcus aureus. In Current Topics in Microbiology and Immunology. Springer Verlag. 2017. p. 21-56. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/82_2016_3
Monaco, Monica ; Pimentel de Araujo, Fernanda ; Cruciani, Melania ; Coccia, Eliana M. ; Pantosti, Annalisa. / Worldwide epidemiology and antibiotic resistance of Staphylococcus aureus. Current Topics in Microbiology and Immunology. Springer Verlag, 2017. pp. 21-56 (Current Topics in Microbiology and Immunology).
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