Worldwide frequency of a common genetic variant of luteinizing hormone: An international collaborative research

Christe Nilsson, Martin M. Matzuk, Kim Pettersson, Ilpo T. Huhtaniemi, Robert P. Millar, Katherine A. Coerver, Marja Liisa Savontaus, Margus Punab, Hana Pisarek, Krzysztof Kula, Tom M. Pettersson, Evert J B Van Santbrink, Bart C J M Fauser, Richard N. Clayton, Paolo Beck-Peccoz, Kenji Fujieda, Anek Aribarg, Chun Nian Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To determine the worldwide frequency of a common immunological LH variant because of two point mutations in the LH β-subunit gene (Trp8Arg and Ile15Thr). Design: Cross-sectional study on LH status (variant and wild-type) in scram (or DNA) samples from Finland (Finns and Lapps), Estonia, Poland, Sweden, The Netherlands, United Kingdom, Italy, South Africa (blacks), Thailand, China, Japan, and the United States (Hispanics and blacks). Setting: Academic research environment. Patient(s): Ambulatory adult men and women (n = 2,936) with minor illnesses and no known endocrinological disorders. Intervention: A single blood sample was collected from each subject. Main Outcome Measure(s): The LH status was determined by two immunofluorometric assays using monoclonal antibodies. One (assay 1) only recognizes the wild-type LH, the other (assay 2) recognizes equally variant and wild-type LH. The ratio of assay 1 to assay 2 indicates the LH status: wild-type, >0.9; heterozygote, 0.2 to 0.9; and homozygote,

Original languageEnglish
Pages (from-to)998-1004
Number of pages7
JournalFertility and Sterility
Volume67
Issue number6
DOIs
Publication statusPublished - Jun 1997

Keywords

  • Ethnic variation
  • Immunoassay
  • Luteinizing hormone
  • Luteinizing hormone variant
  • Mutation
  • Polymorphism

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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