Wound healing kinetics of the genetically diabetic mouse

Sandra Saja Scherer, Giorgio Pietramaggiori, Jasmine C. Mathews, Rodney Chan, Paolo Fiorina, Dennis P. Orgill

Research output: Contribution to journalArticle

Abstract

The increased number of chronic nonhealing wounds mirrors the epidemic of type 2 diabetes. Diabetic animal models may allow for better understanding of the pathophysiology of wound healing and may lead to the pre-clinical testing of a variety of therapeutic modalities for this patient group. The authors present an overview of the literature on excisional wound mouse models and focus on the authorsĝ€™ experience with the db/db mouse. Excisional wounds in wild type mice heal quickly due primarily to wound contraction, which is delayed in the db/db mouse. In this animal model it is possible to study and quantify the main mechanisms of healing and produce highly reproducible information. Differences in methodologies, infection control, as well as fine details such as the dressing option, partially explain heterogeneous results in the literature. Given the increase of the diabetic population, the db/db mouse model provides a powerful tool to study the effects of therapeutics for improving wound healing. The standardization of this animal model represents an important aspect to improve in the wound care field.

Original languageEnglish
Pages (from-to)18-28
Number of pages11
JournalWounds
Volume20
Issue number1
Publication statusPublished - Jan 2008

Keywords

  • Autolytic debridement
  • Compression stockings
  • Delayed wound healing
  • Diabetic foot wounds
  • Impaired wound healing
  • Mechanical debridement
  • Pressure dressing
  • Surgical debridement
  • Wound fibroblasts
  • Wound necrosis

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Scherer, S. S., Pietramaggiori, G., Mathews, J. C., Chan, R., Fiorina, P., & Orgill, D. P. (2008). Wound healing kinetics of the genetically diabetic mouse. Wounds, 20(1), 18-28.