X monosomy in female systemic lupus erythematosus

Pietro Invernizzi, Monica Miozzo, Sabine Oertelt-Prigione, Pier Luigi Meroni, Luca Persani, Carlo Selmi, Pier Maria Battezzati, Massimo Zuin, Simona Lucchi, Bianca Marasini, Silvana Zeni, Mitchell Watnik, Silvia Tabano, Silvia Maitz, Simone Pasini, M. Eric Gershwin, Mauro Podda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

40 Citations (Scopus)

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, predominantly occurring in women of childbearing age. SLE, like several other autoimmune diseases, is characterized by a striking female predominance and, although sex hormone influences have been suggested as an explanation for this phenomenon, definitive data are still unavailable. Our group recently reported an increased X monosomy in lymphocytes of women, affected with primary biliary cirrhosis (PBC), systemic sclerosis (SSc), and autoimmune thyroiditis (AITD) in comparison to healthy women, thus suggesting the involvement of this chromosome in female predominance and in the deregulation of the immune system that characterizes autoimmunity. We have no we valuated X monosomy rates in SLE using fluorescence in situ hybridization (FISH) on peripheral mononuclear white blood cells (PBMCs) from female patients compared to healthy age-matched controls. In addition, because of a previous finding of microchimerism as a pathogenetic cause of a number of autoimmune diseases, we investigated the presence of cells carrying the Y chromosome. We did not identify an increased X monosomy in women with SLE compared to controls (P = 0.3960, SLE vs. HCs, Student's ttest), thus suggesting that a different mechanism of immune deregulation might be predominant in the female population of patients with SLE.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages84-91
Number of pages8
Volume1110
DOIs
Publication statusPublished - Sep 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1110
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Turner Syndrome
Systemic Lupus Erythematosus
Deregulation
Chromosomes
Autoimmune Diseases
Lymphocytes
Immune system
Gonadal Steroid Hormones
Blood
Fluorescence
Cells
Students
Autoimmune Thyroiditis
Chimerism
Biliary Liver Cirrhosis
Systemic Scleroderma
Y Chromosome
Fluorescence In Situ Hybridization
Autoimmunity
Immune System

Keywords

  • AITD
  • Autoimmune thyroiditis
  • PBC
  • Primary biliary cirrhosis
  • SLE
  • Systemic lupus erythematosus
  • X monosomy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Invernizzi, P., Miozzo, M., Oertelt-Prigione, S., Meroni, P. L., Persani, L., Selmi, C., ... Podda, M. (2007). X monosomy in female systemic lupus erythematosus. In Annals of the New York Academy of Sciences (Vol. 1110, pp. 84-91). (Annals of the New York Academy of Sciences; Vol. 1110). https://doi.org/10.1196/annals.1423.010

X monosomy in female systemic lupus erythematosus. / Invernizzi, Pietro; Miozzo, Monica; Oertelt-Prigione, Sabine; Meroni, Pier Luigi; Persani, Luca; Selmi, Carlo; Battezzati, Pier Maria; Zuin, Massimo; Lucchi, Simona; Marasini, Bianca; Zeni, Silvana; Watnik, Mitchell; Tabano, Silvia; Maitz, Silvia; Pasini, Simone; Gershwin, M. Eric; Podda, Mauro.

Annals of the New York Academy of Sciences. Vol. 1110 2007. p. 84-91 (Annals of the New York Academy of Sciences; Vol. 1110).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Invernizzi, P, Miozzo, M, Oertelt-Prigione, S, Meroni, PL, Persani, L, Selmi, C, Battezzati, PM, Zuin, M, Lucchi, S, Marasini, B, Zeni, S, Watnik, M, Tabano, S, Maitz, S, Pasini, S, Gershwin, ME & Podda, M 2007, X monosomy in female systemic lupus erythematosus. in Annals of the New York Academy of Sciences. vol. 1110, Annals of the New York Academy of Sciences, vol. 1110, pp. 84-91. https://doi.org/10.1196/annals.1423.010
Invernizzi P, Miozzo M, Oertelt-Prigione S, Meroni PL, Persani L, Selmi C et al. X monosomy in female systemic lupus erythematosus. In Annals of the New York Academy of Sciences. Vol. 1110. 2007. p. 84-91. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1423.010
Invernizzi, Pietro ; Miozzo, Monica ; Oertelt-Prigione, Sabine ; Meroni, Pier Luigi ; Persani, Luca ; Selmi, Carlo ; Battezzati, Pier Maria ; Zuin, Massimo ; Lucchi, Simona ; Marasini, Bianca ; Zeni, Silvana ; Watnik, Mitchell ; Tabano, Silvia ; Maitz, Silvia ; Pasini, Simone ; Gershwin, M. Eric ; Podda, Mauro. / X monosomy in female systemic lupus erythematosus. Annals of the New York Academy of Sciences. Vol. 1110 2007. pp. 84-91 (Annals of the New York Academy of Sciences).
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