X-sizer for thrombectomy in acute myocardial infarction improves ST-segment resolution: Results of the X-sizer in AMI for negligible embolization and optimal ST resolution (X AMINE ST) trial

Thierry Lefèvre, Eulegio Garcia, Bernhard Reimers, Iréne Lang, Carlo Di Mario, Antonio Colombo, Franz Joseph Neumann, Mariano Valdés Chavarri, Philippe Brunel, Eberhart Grube, Martin Thomas, Bernard Glatt, Joseph Ludwig

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: We sought to compare, in a prospective randomized multicenter study, the effect of adjunctive thrombectomy using X-Sizer (eV3, White Bear Lake, Minnesota) before percutaneous coronary intervention (PCI) versus conventional PCI in patients with acute myocardial infarction (AMI) for 50% (68% vs. 53%; p = 0.037). The occurrence of distal embolization was reduced (2% vs. 10%; p = 0.033) and TIMI flow grade 3 was obtained in 96% vs. 89%, respectively (p = 0.105). Myocardial blush grade 3 was similar (30% vs. 31%; p = NS). Six-month clinical outcome was comparable (death, 6% vs. 4% and major adverse cardiac and cerebral events, 13% vs. 13%, respectively). By multivariate analysis, independent predictors of ST-segment resolution >50% were: younger age, non-anterior MI, use of the X-Sizer, and a short time interval from symptom onset. CONCLUSIONS: Reducing thrombus burden with X-Sizer before stenting leads to better myocardial reperfusion, as illustrated by a reduced risk of distal embolization and better ST-segment resolution.

Original languageEnglish
Pages (from-to)246-252
Number of pages7
JournalJournal of the American College of Cardiology
Volume46
Issue number2
DOIs
Publication statusPublished - Jul 19 2005

ASJC Scopus subject areas

  • Nursing(all)

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