@inbook{efe795d79f5340c9a1a8fd3f17ab0b1b,
title = "Xenograft as in vivo experimental model",
abstract = "The identification of experimental models that recapitulate human cancers designed to predict patient clinical response to therapies is a major break in oncology. Cancer stem cells (CSCs) represent a small tumor cell population responsible for drug resistance, where their effective killing may lead to identifying better treatment options. While the CSCs hypothesis highlights the need for a specific tumor target, patient-derived xenografts (PDXs) should also be considered for drug development as they better represent tumor heterogeneity and the environment in which a tumor develops.",
keywords = "Heterogeneity, Immunosuppressed mice, Patient-derived xenografts, Predictive model, Stroma, Transplantation assay, Tumorigenicity",
author = "Manuela Porru and Luca Pompili and Carla Caruso and Carlo Leonetti",
year = "2018",
month = jan,
day = "1",
doi = "10.1007/978-1-4939-7401-6_9",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "97--105",
booktitle = "Methods in Molecular Biology",
}