Xenograft as in vivo experimental model

Manuela Porru, Luca Pompili, Carla Caruso, Carlo Leonetti

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The identification of experimental models that recapitulate human cancers designed to predict patient clinical response to therapies is a major break in oncology. Cancer stem cells (CSCs) represent a small tumor cell population responsible for drug resistance, where their effective killing may lead to identifying better treatment options. While the CSCs hypothesis highlights the need for a specific tumor target, patient-derived xenografts (PDXs) should also be considered for drug development as they better represent tumor heterogeneity and the environment in which a tumor develops.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages97-105
Number of pages9
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameMethods in Molecular Biology
Volume1692
ISSN (Print)1064-3745

Keywords

  • Heterogeneity
  • Immunosuppressed mice
  • Patient-derived xenografts
  • Predictive model
  • Stroma
  • Transplantation assay
  • Tumorigenicity

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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