Xenotropic and polytropic murine leukemia virus-related sequences are not detected in the majority of patients with chronic fatigue syndrome

Stefania Paolucci, Antonio Piralla, Cinzia Zanello, Lorenzo Minoli, Fausto Baldanti

Research output: Contribution to journalArticlepeer-review

Abstract

XMRV and polytropic MLV-related virus have been controversially associated with chronic fatigue syndrome (CFS). Subsequent reports failed to detect XMRV and MLV-related virus in CFS patients, and the previous results have been interpreted as a massive laboratory contamination by mouse DNA sequences. Among 12 sequential CFS patients, two were positive for XMRV/MLV sequences. In contrast, 40 selected control subjects were negative. CSF patients and controls were negative for mitochondrial mouse-specific DNA sequences. These findings do not confirm the high frequency of MLV-related viruses infection in CFS patients, but also contrast the widespread laboratory contamination previously suggested.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalNew Microbiologica
Volume35
Issue number3
Publication statusPublished - 2012

Keywords

  • Chronic fatigue syndrome
  • Ecotropic MLV
  • MLV-related virus
  • Polytropic MLV
  • XMRV

ASJC Scopus subject areas

  • Microbiology (medical)

Fingerprint Dive into the research topics of 'Xenotropic and polytropic murine leukemia virus-related sequences are not detected in the majority of patients with chronic fatigue syndrome'. Together they form a unique fingerprint.

Cite this