Abstract
XMRV and polytropic MLV-related virus have been controversially associated with chronic fatigue syndrome (CFS). Subsequent reports failed to detect XMRV and MLV-related virus in CFS patients, and the previous results have been interpreted as a massive laboratory contamination by mouse DNA sequences. Among 12 sequential CFS patients, two were positive for XMRV/MLV sequences. In contrast, 40 selected control subjects were negative. CSF patients and controls were negative for mitochondrial mouse-specific DNA sequences. These findings do not confirm the high frequency of MLV-related viruses infection in CFS patients, but also contrast the widespread laboratory contamination previously suggested.
| Original language | English |
|---|---|
| Pages (from-to) | 341-344 |
| Number of pages | 4 |
| Journal | New Microbiologica |
| Volume | 35 |
| Issue number | 3 |
| Publication status | Published - 2012 |
Keywords
- Chronic fatigue syndrome
- Ecotropic MLV
- MLV-related virus
- Polytropic MLV
- XMRV
ASJC Scopus subject areas
- Microbiology (medical)