XIAP: Inhibitor of two worlds

Paola Merlo, Francesco Cecconi

Research output: Contribution to journalArticlepeer-review


Autophagy is a catabolic mechanism that selectively eliminates long-lived proteins, aggregates and damaged organelles and is thereby fundamental in maintaining cellular homeostasis. As a prosurvival mechanism, autophagy is carefully regulated and its dysfunction is associated with cancer development. Work of Huang et al (2013) in this issue of The EMBO Journal identifies the apoptosis inhibitor XIAP as a novel repressor of autophagy-a function that significantly contributes to its tumorigenecity.

Original languageEnglish
Pages (from-to)2187-2188
Number of pages2
JournalEMBO Journal
Issue number16
Publication statusPublished - Aug 14 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)


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