Xipamide treatment in congestive heart failure

Double-blind trial with furosemide

D. Bonaduce, N. Ferrara, V. Canonico

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A double-blind trial was undertaken to investigate the efficacy and side effects of xipamide, a new diuretic, in comparison with furosemide in the treatment of patients with congestive heart failure. The study population comprised thirty patients randomized in two groups (A and B). Those in Group A received 1 capsule of furosemide (25 mg) and those in Group B 1 capsule of xipamide (40 mg) every day for 7 days. Body weight, water balance, 24-hour urine Na+ and K+ content, urine osmolarity, plasma Na+ and K+ concentrations, and plasma osmolarity were evaluated during treatment. Systolic and diastolic pressure and heart rate were measured every day before capsule administration. All parameters considered showed comparable variations; in particular body weight, Na+ and K+ plasma levels were reduced while water balance, Na+ and K+ urine content were increased with both drugs. Blood uric acid levels increased. In conclusion xipamide is a new powerful diuretic whose efficacy in the treatment of water retention is comparable to that of furosemide.

Original languageEnglish
Pages (from-to)293-301
Number of pages9
JournalCurrent Therapeutic Research
Volume31
Issue number3 I
Publication statusPublished - 1982

Fingerprint

Xipamide
Furosemide
Capsules
Heart Failure
Urine
Diuretics
Osmolar Concentration
Body Weight
Blood Pressure
Body Water
Water Purification
Uric Acid
Therapeutics
Heart Rate
Water
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Xipamide treatment in congestive heart failure : Double-blind trial with furosemide. / Bonaduce, D.; Ferrara, N.; Canonico, V.

In: Current Therapeutic Research, Vol. 31, No. 3 I, 1982, p. 293-301.

Research output: Contribution to journalArticle

Bonaduce, D, Ferrara, N & Canonico, V 1982, 'Xipamide treatment in congestive heart failure: Double-blind trial with furosemide', Current Therapeutic Research, vol. 31, no. 3 I, pp. 293-301.
Bonaduce, D. ; Ferrara, N. ; Canonico, V. / Xipamide treatment in congestive heart failure : Double-blind trial with furosemide. In: Current Therapeutic Research. 1982 ; Vol. 31, No. 3 I. pp. 293-301.
@article{9ee5ae4b970349e8a1c826b13e5031de,
title = "Xipamide treatment in congestive heart failure: Double-blind trial with furosemide",
abstract = "A double-blind trial was undertaken to investigate the efficacy and side effects of xipamide, a new diuretic, in comparison with furosemide in the treatment of patients with congestive heart failure. The study population comprised thirty patients randomized in two groups (A and B). Those in Group A received 1 capsule of furosemide (25 mg) and those in Group B 1 capsule of xipamide (40 mg) every day for 7 days. Body weight, water balance, 24-hour urine Na+ and K+ content, urine osmolarity, plasma Na+ and K+ concentrations, and plasma osmolarity were evaluated during treatment. Systolic and diastolic pressure and heart rate were measured every day before capsule administration. All parameters considered showed comparable variations; in particular body weight, Na+ and K+ plasma levels were reduced while water balance, Na+ and K+ urine content were increased with both drugs. Blood uric acid levels increased. In conclusion xipamide is a new powerful diuretic whose efficacy in the treatment of water retention is comparable to that of furosemide.",
author = "D. Bonaduce and N. Ferrara and V. Canonico",
year = "1982",
language = "English",
volume = "31",
pages = "293--301",
journal = "Current Therapeutic Research - Clinical and Experimental",
issn = "0011-393X",
publisher = "Excerpta Medica",
number = "3 I",

}

TY - JOUR

T1 - Xipamide treatment in congestive heart failure

T2 - Double-blind trial with furosemide

AU - Bonaduce, D.

AU - Ferrara, N.

AU - Canonico, V.

PY - 1982

Y1 - 1982

N2 - A double-blind trial was undertaken to investigate the efficacy and side effects of xipamide, a new diuretic, in comparison with furosemide in the treatment of patients with congestive heart failure. The study population comprised thirty patients randomized in two groups (A and B). Those in Group A received 1 capsule of furosemide (25 mg) and those in Group B 1 capsule of xipamide (40 mg) every day for 7 days. Body weight, water balance, 24-hour urine Na+ and K+ content, urine osmolarity, plasma Na+ and K+ concentrations, and plasma osmolarity were evaluated during treatment. Systolic and diastolic pressure and heart rate were measured every day before capsule administration. All parameters considered showed comparable variations; in particular body weight, Na+ and K+ plasma levels were reduced while water balance, Na+ and K+ urine content were increased with both drugs. Blood uric acid levels increased. In conclusion xipamide is a new powerful diuretic whose efficacy in the treatment of water retention is comparable to that of furosemide.

AB - A double-blind trial was undertaken to investigate the efficacy and side effects of xipamide, a new diuretic, in comparison with furosemide in the treatment of patients with congestive heart failure. The study population comprised thirty patients randomized in two groups (A and B). Those in Group A received 1 capsule of furosemide (25 mg) and those in Group B 1 capsule of xipamide (40 mg) every day for 7 days. Body weight, water balance, 24-hour urine Na+ and K+ content, urine osmolarity, plasma Na+ and K+ concentrations, and plasma osmolarity were evaluated during treatment. Systolic and diastolic pressure and heart rate were measured every day before capsule administration. All parameters considered showed comparable variations; in particular body weight, Na+ and K+ plasma levels were reduced while water balance, Na+ and K+ urine content were increased with both drugs. Blood uric acid levels increased. In conclusion xipamide is a new powerful diuretic whose efficacy in the treatment of water retention is comparable to that of furosemide.

UR - http://www.scopus.com/inward/record.url?scp=0020034687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020034687&partnerID=8YFLogxK

M3 - Article

VL - 31

SP - 293

EP - 301

JO - Current Therapeutic Research - Clinical and Experimental

JF - Current Therapeutic Research - Clinical and Experimental

SN - 0011-393X

IS - 3 I

ER -