A double-blind trial was undertaken to investigate the efficacy and side effects of xipamide, a new diuretic, in comparison with furosemide in the treatment of patients with congestive heart failure. The study population comprised thirty patients randomized in two groups (A and B). Those in Group A received 1 capsule of furosemide (25 mg) and those in Group B 1 capsule of xipamide (40 mg) every day for 7 days. Body weight, water balance, 24-hour urine Na+ and K+ content, urine osmolarity, plasma Na+ and K+ concentrations, and plasma osmolarity were evaluated during treatment. Systolic and diastolic pressure and heart rate were measured every day before capsule administration. All parameters considered showed comparable variations; in particular body weight, Na+ and K+ plasma levels were reduced while water balance, Na+ and K+ urine content were increased with both drugs. Blood uric acid levels increased. In conclusion xipamide is a new powerful diuretic whose efficacy in the treatment of water retention is comparable to that of furosemide.
|Number of pages||9|
|Journal||Current Therapeutic Research|
|Issue number||3 I|
|Publication status||Published - 1982|
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