Abstract
We report a 46,XY 11-year-old girl with pure gonadal dysgenesis who developed a dysgerminoma. The testis-determining gene SRY, a candidate for sex reversal, whose alterations seem to correlate with dysgerminoma, was analyzed and found to be normal; its coding sequence was negative for deletions and mutations. DMRT-1 gene mapping on 9p and DAX-1 on Xp21 were also normal. These results suggest the involvement of other genes in sex reversal and call into question the putative relationship between SRY alterations and dysgerminoma.
| Original language | English |
|---|---|
| Pages (from-to) | 58-61 |
| Number of pages | 4 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 136 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1 2002 |
ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
Fingerprint Dive into the research topics of 'XY female with a dysgerminoma and no mutation in the coding sequence of the SRY gene'. Together they form a unique fingerprint.
Cite this
Morerio, C., Calvari, V., Rosanda, C., Porta, S., Gambini, C., & Panarello, C. (2002). XY female with a dysgerminoma and no mutation in the coding sequence of the SRY gene. Cancer Genetics and Cytogenetics, 136(1), 58-61. https://doi.org/10.1016/S0165-4608(01)00662-8