YAP and p73: A matter of mutual specificity in tumor suppression

Sara Donzelli; Sabrina Strano; Giovanni Blandino

doi:10.1007/978-1-4614-6220-0_8

YAP and p73: A matter of mutual specificity in tumor suppression

Sara Donzelli, Sabrina Strano, Giovanni Blandino

Istituto Regina Elena

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

YAP and p73 proteins are key nodes of two distinct tumor suppressor pathways. The HIPPO tumor suppressor pathway to which YAP belongs is the most recent identified in the cancer arena, while that of the p53 family including p73 is the most well studied and characterized. Often in response to anticancer treatment, distinct tumor suppressor pathways can be triggered and cross talk each other. This is well represented by the growing experimental evidence linking HIPPO and p53 family tumor suppressor pathways. Here we mainly focus on the physical and functional interaction between YAP and p73 proteins, their role in drug-induced apoptosis and their implications in tumor suppression.

Original language	English
Title of host publication	The Hippo Signaling Pathway and Cancer
Publisher	Springer New York
Pages	147-172
Number of pages	26
Volume	9781461462200
ISBN (Print)	9781461462200, 1461462193, 9781461462194
DOIs	https://doi.org/10.1007/978-1-4614-6220-0_8
Publication status	Published - Mar 1 2013

Keywords

Apoptosis
Interaction
p73
Pathway
YAP

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1007/978-1-4614-6220-0_8

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