Abstract
Background: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim: To assess how many years of life are lost after HCC diagnosis. Methods: Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results: Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18-61 years) had the highest number of years-of-life lost, representing approximately 41% of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986-1999, to 10.7 in 2000-2006 and 7.4 years in 2007-2014. Currently, an HCC diagnosis when a single tumour
| Original language | English |
|---|---|
| Pages (from-to) | 814-824 |
| Number of pages | 11 |
| Journal | Alimentary Pharmacology and Therapeutics |
| Volume | 43 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Apr 1 2016 |
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ASJC Scopus subject areas
- Pharmacology (medical)
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Years of life that could be saved from prevention of hepatocellular carcinoma. / Cucchetti, A.; Trevisani, F.; Bucci, L.; Ravaioli, M.; Farinati, F.; Giannini, E. G.; Ciccarese, F.; Piscaglia, F.; Rapaccini, G. L.; Di Marco, M.; Caturelli, E.; Zoli, M.; Borzio, F.; Sacco, R.; Maida, M.; Felder, M.; Morisco, F.; Gasbarrini, A.; Gemini, S.; Foschi, F. G.; Missale, G.; Masotto, A.; Affronti, A.; Bernardi, M.; Pinna, A. D.; Bolondi, Luigi; Biselli, Maurizio; Caraceni, Paolo; Domenicali, Marco; Gramenzi, Annagiulia; Magalotti, Donatella; Pecorelli, Anna; Serra, Carla; Venerandi, Laura; Gazzola, Alessia; Murer, Francesca; Pozzan, Caterina; Vanin, Veronica; Del Poggio, Paolo; Olmi, Stefano; Balsamo, Claudia; Vavassori, Elena; Benvegnù, Luisa; Cappelli, Alberta; Golfieri, Rita; Mosconi, Cristina; Renzulli, Matteo; Bosco, Giulia; Roselli, Paola; Dell'Isola, Serena; Lalungo, Anna Maria; Rastrelli, Elena; Moscatelli, Alessandro; Pellegatta, Gaia; Picciotto, Antonino; Savarino, Vincenzo; Barcellona, Maria Rosa; Cammà, Calogero; Cabibbo, Giuseppe; Costantino, Andrea; Virdone, Roberto; Mega, Andrea; Rinninella, Emanuele; Mismas, Valeria; Dall'Aglio, Anna Chiara; Feletti, Valentina; Lanzi, Arianna; Cappa, Federica Mirici; Neri, Elga; Stefanini, Giuseppe Francesco; Tamberi, Stefano; Biasini, Elisabetta; Porro, Emanuela; Guarino, Maria; Baroni, Gianluca Svegliati; Schiadà, Laura; Chiaramonte, Maria; Marchetti, Fabiana; Valerio, Matteo.
In: Alimentary Pharmacology and Therapeutics, Vol. 43, No. 7, 01.04.2016, p. 814-824.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Years of life that could be saved from prevention of hepatocellular carcinoma
AU - Cucchetti, A.
AU - Trevisani, F.
AU - Bucci, L.
AU - Ravaioli, M.
AU - Farinati, F.
AU - Giannini, E. G.
AU - Ciccarese, F.
AU - Piscaglia, F.
AU - Rapaccini, G. L.
AU - Di Marco, M.
AU - Caturelli, E.
AU - Zoli, M.
AU - Borzio, F.
AU - Sacco, R.
AU - Maida, M.
AU - Felder, M.
AU - Morisco, F.
AU - Gasbarrini, A.
AU - Gemini, S.
AU - Foschi, F. G.
AU - Missale, G.
AU - Masotto, A.
AU - Affronti, A.
AU - Bernardi, M.
AU - Pinna, A. D.
AU - Bolondi, Luigi
AU - Biselli, Maurizio
AU - Caraceni, Paolo
AU - Domenicali, Marco
AU - Gramenzi, Annagiulia
AU - Magalotti, Donatella
AU - Pecorelli, Anna
AU - Serra, Carla
AU - Venerandi, Laura
AU - Gazzola, Alessia
AU - Murer, Francesca
AU - Pozzan, Caterina
AU - Vanin, Veronica
AU - Del Poggio, Paolo
AU - Olmi, Stefano
AU - Balsamo, Claudia
AU - Vavassori, Elena
AU - Benvegnù, Luisa
AU - Cappelli, Alberta
AU - Golfieri, Rita
AU - Mosconi, Cristina
AU - Renzulli, Matteo
AU - Bosco, Giulia
AU - Roselli, Paola
AU - Dell'Isola, Serena
AU - Lalungo, Anna Maria
AU - Rastrelli, Elena
AU - Moscatelli, Alessandro
AU - Pellegatta, Gaia
AU - Picciotto, Antonino
AU - Savarino, Vincenzo
AU - Barcellona, Maria Rosa
AU - Cammà, Calogero
AU - Cabibbo, Giuseppe
AU - Costantino, Andrea
AU - Virdone, Roberto
AU - Mega, Andrea
AU - Rinninella, Emanuele
AU - Mismas, Valeria
AU - Dall'Aglio, Anna Chiara
AU - Feletti, Valentina
AU - Lanzi, Arianna
AU - Cappa, Federica Mirici
AU - Neri, Elga
AU - Stefanini, Giuseppe Francesco
AU - Tamberi, Stefano
AU - Biasini, Elisabetta
AU - Porro, Emanuela
AU - Guarino, Maria
AU - Baroni, Gianluca Svegliati
AU - Schiadà, Laura
AU - Chiaramonte, Maria
AU - Marchetti, Fabiana
AU - Valerio, Matteo
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Background: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim: To assess how many years of life are lost after HCC diagnosis. Methods: Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results: Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18-61 years) had the highest number of years-of-life lost, representing approximately 41% of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986-1999, to 10.7 in 2000-2006 and 7.4 years in 2007-2014. Currently, an HCC diagnosis when a single tumour
AB - Background: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim: To assess how many years of life are lost after HCC diagnosis. Methods: Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results: Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18-61 years) had the highest number of years-of-life lost, representing approximately 41% of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986-1999, to 10.7 in 2000-2006 and 7.4 years in 2007-2014. Currently, an HCC diagnosis when a single tumour
UR - http://www.scopus.com/inward/record.url?scp=84959479781&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959479781&partnerID=8YFLogxK
U2 - 10.1111/apt.13554
DO - 10.1111/apt.13554
M3 - Article
AN - SCOPUS:84959479781
VL - 43
SP - 814
EP - 824
JO - Alimentary Pharmacology and Therapeutics
JF - Alimentary Pharmacology and Therapeutics
SN - 0269-2813
IS - 7
ER -