Years of life that could be saved from prevention of hepatocellular carcinoma

A. Cucchetti, F. Trevisani, L. Bucci, M. Ravaioli, F. Farinati, E. G. Giannini, F. Ciccarese, F. Piscaglia, G. L. Rapaccini, M. Di Marco, E. Caturelli, M. Zoli, F. Borzio, R. Sacco, M. Maida, M. Felder, F. Morisco, A. Gasbarrini, S. Gemini, F. G. FoschiG. Missale, A. Masotto, A. Affronti, M. Bernardi, A. D. Pinna, Luigi Bolondi, Maurizio Biselli, Paolo Caraceni, Marco Domenicali, Annagiulia Gramenzi, Donatella Magalotti, Anna Pecorelli, Carla Serra, Laura Venerandi, Alessia Gazzola, Francesca Murer, Caterina Pozzan, Veronica Vanin, Paolo Del Poggio, Stefano Olmi, Claudia Balsamo, Elena Vavassori, Luisa Benvegnù, Alberta Cappelli, Rita Golfieri, Cristina Mosconi, Matteo Renzulli, Giulia Bosco, Paola Roselli, Serena Dell'Isola, Anna Maria Lalungo, Elena Rastrelli, Alessandro Moscatelli, Gaia Pellegatta, Antonino Picciotto, Vincenzo Savarino, Maria Rosa Barcellona, Calogero Cammà, Giuseppe Cabibbo, Andrea Costantino, Roberto Virdone, Andrea Mega, Emanuele Rinninella, Valeria Mismas, Anna Chiara Dall'Aglio, Valentina Feletti, Arianna Lanzi, Federica Mirici Cappa, Elga Neri, Giuseppe Francesco Stefanini, Stefano Tamberi, Elisabetta Biasini, Emanuela Porro, Maria Guarino, Gianluca Svegliati Baroni, Laura Schiadà, Maria Chiaramonte, Fabiana Marchetti, Matteo Valerio

Research output: Contribution to journalArticle

Abstract

Background: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim: To assess how many years of life are lost after HCC diagnosis. Methods: Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results: Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18-61 years) had the highest number of years-of-life lost, representing approximately 41% of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986-1999, to 10.7 in 2000-2006 and 7.4 years in 2007-2014. Currently, an HCC diagnosis when a single tumour

Original languageEnglish
Pages (from-to)814-824
Number of pages11
JournalAlimentary Pharmacology and Therapeutics
Volume43
Issue number7
DOIs
Publication statusPublished - Apr 1 2016

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Hepatocellular Carcinoma
Premature Mortality
Life Tables
Primary Prevention
Secondary Prevention
Life Expectancy
Cause of Death
Neoplasms
Age Groups
Population

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Cucchetti, A., Trevisani, F., Bucci, L., Ravaioli, M., Farinati, F., Giannini, E. G., ... Valerio, M. (2016). Years of life that could be saved from prevention of hepatocellular carcinoma. Alimentary Pharmacology and Therapeutics, 43(7), 814-824. https://doi.org/10.1111/apt.13554

Years of life that could be saved from prevention of hepatocellular carcinoma. / Cucchetti, A.; Trevisani, F.; Bucci, L.; Ravaioli, M.; Farinati, F.; Giannini, E. G.; Ciccarese, F.; Piscaglia, F.; Rapaccini, G. L.; Di Marco, M.; Caturelli, E.; Zoli, M.; Borzio, F.; Sacco, R.; Maida, M.; Felder, M.; Morisco, F.; Gasbarrini, A.; Gemini, S.; Foschi, F. G.; Missale, G.; Masotto, A.; Affronti, A.; Bernardi, M.; Pinna, A. D.; Bolondi, Luigi; Biselli, Maurizio; Caraceni, Paolo; Domenicali, Marco; Gramenzi, Annagiulia; Magalotti, Donatella; Pecorelli, Anna; Serra, Carla; Venerandi, Laura; Gazzola, Alessia; Murer, Francesca; Pozzan, Caterina; Vanin, Veronica; Del Poggio, Paolo; Olmi, Stefano; Balsamo, Claudia; Vavassori, Elena; Benvegnù, Luisa; Cappelli, Alberta; Golfieri, Rita; Mosconi, Cristina; Renzulli, Matteo; Bosco, Giulia; Roselli, Paola; Dell'Isola, Serena; Lalungo, Anna Maria; Rastrelli, Elena; Moscatelli, Alessandro; Pellegatta, Gaia; Picciotto, Antonino; Savarino, Vincenzo; Barcellona, Maria Rosa; Cammà, Calogero; Cabibbo, Giuseppe; Costantino, Andrea; Virdone, Roberto; Mega, Andrea; Rinninella, Emanuele; Mismas, Valeria; Dall'Aglio, Anna Chiara; Feletti, Valentina; Lanzi, Arianna; Cappa, Federica Mirici; Neri, Elga; Stefanini, Giuseppe Francesco; Tamberi, Stefano; Biasini, Elisabetta; Porro, Emanuela; Guarino, Maria; Baroni, Gianluca Svegliati; Schiadà, Laura; Chiaramonte, Maria; Marchetti, Fabiana; Valerio, Matteo.

In: Alimentary Pharmacology and Therapeutics, Vol. 43, No. 7, 01.04.2016, p. 814-824.

Research output: Contribution to journalArticle

Cucchetti, A, Trevisani, F, Bucci, L, Ravaioli, M, Farinati, F, Giannini, EG, Ciccarese, F, Piscaglia, F, Rapaccini, GL, Di Marco, M, Caturelli, E, Zoli, M, Borzio, F, Sacco, R, Maida, M, Felder, M, Morisco, F, Gasbarrini, A, Gemini, S, Foschi, FG, Missale, G, Masotto, A, Affronti, A, Bernardi, M, Pinna, AD, Bolondi, L, Biselli, M, Caraceni, P, Domenicali, M, Gramenzi, A, Magalotti, D, Pecorelli, A, Serra, C, Venerandi, L, Gazzola, A, Murer, F, Pozzan, C, Vanin, V, Del Poggio, P, Olmi, S, Balsamo, C, Vavassori, E, Benvegnù, L, Cappelli, A, Golfieri, R, Mosconi, C, Renzulli, M, Bosco, G, Roselli, P, Dell'Isola, S, Lalungo, AM, Rastrelli, E, Moscatelli, A, Pellegatta, G, Picciotto, A, Savarino, V, Barcellona, MR, Cammà, C, Cabibbo, G, Costantino, A, Virdone, R, Mega, A, Rinninella, E, Mismas, V, Dall'Aglio, AC, Feletti, V, Lanzi, A, Cappa, FM, Neri, E, Stefanini, GF, Tamberi, S, Biasini, E, Porro, E, Guarino, M, Baroni, GS, Schiadà, L, Chiaramonte, M, Marchetti, F & Valerio, M 2016, 'Years of life that could be saved from prevention of hepatocellular carcinoma', Alimentary Pharmacology and Therapeutics, vol. 43, no. 7, pp. 814-824. https://doi.org/10.1111/apt.13554
Cucchetti, A. ; Trevisani, F. ; Bucci, L. ; Ravaioli, M. ; Farinati, F. ; Giannini, E. G. ; Ciccarese, F. ; Piscaglia, F. ; Rapaccini, G. L. ; Di Marco, M. ; Caturelli, E. ; Zoli, M. ; Borzio, F. ; Sacco, R. ; Maida, M. ; Felder, M. ; Morisco, F. ; Gasbarrini, A. ; Gemini, S. ; Foschi, F. G. ; Missale, G. ; Masotto, A. ; Affronti, A. ; Bernardi, M. ; Pinna, A. D. ; Bolondi, Luigi ; Biselli, Maurizio ; Caraceni, Paolo ; Domenicali, Marco ; Gramenzi, Annagiulia ; Magalotti, Donatella ; Pecorelli, Anna ; Serra, Carla ; Venerandi, Laura ; Gazzola, Alessia ; Murer, Francesca ; Pozzan, Caterina ; Vanin, Veronica ; Del Poggio, Paolo ; Olmi, Stefano ; Balsamo, Claudia ; Vavassori, Elena ; Benvegnù, Luisa ; Cappelli, Alberta ; Golfieri, Rita ; Mosconi, Cristina ; Renzulli, Matteo ; Bosco, Giulia ; Roselli, Paola ; Dell'Isola, Serena ; Lalungo, Anna Maria ; Rastrelli, Elena ; Moscatelli, Alessandro ; Pellegatta, Gaia ; Picciotto, Antonino ; Savarino, Vincenzo ; Barcellona, Maria Rosa ; Cammà, Calogero ; Cabibbo, Giuseppe ; Costantino, Andrea ; Virdone, Roberto ; Mega, Andrea ; Rinninella, Emanuele ; Mismas, Valeria ; Dall'Aglio, Anna Chiara ; Feletti, Valentina ; Lanzi, Arianna ; Cappa, Federica Mirici ; Neri, Elga ; Stefanini, Giuseppe Francesco ; Tamberi, Stefano ; Biasini, Elisabetta ; Porro, Emanuela ; Guarino, Maria ; Baroni, Gianluca Svegliati ; Schiadà, Laura ; Chiaramonte, Maria ; Marchetti, Fabiana ; Valerio, Matteo. / Years of life that could be saved from prevention of hepatocellular carcinoma. In: Alimentary Pharmacology and Therapeutics. 2016 ; Vol. 43, No. 7. pp. 814-824.
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abstract = "Background: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim: To assess how many years of life are lost after HCC diagnosis. Methods: Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results: Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18-61 years) had the highest number of years-of-life lost, representing approximately 41{\%} of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986-1999, to 10.7 in 2000-2006 and 7.4 years in 2007-2014. Currently, an HCC diagnosis when a single tumour",
author = "A. Cucchetti and F. Trevisani and L. Bucci and M. Ravaioli and F. Farinati and Giannini, {E. G.} and F. Ciccarese and F. Piscaglia and Rapaccini, {G. L.} and {Di Marco}, M. and E. Caturelli and M. Zoli and F. Borzio and R. Sacco and M. Maida and M. Felder and F. Morisco and A. Gasbarrini and S. Gemini and Foschi, {F. G.} and G. Missale and A. Masotto and A. Affronti and M. Bernardi and Pinna, {A. D.} and Luigi Bolondi and Maurizio Biselli and Paolo Caraceni and Marco Domenicali and Annagiulia Gramenzi and Donatella Magalotti and Anna Pecorelli and Carla Serra and Laura Venerandi and Alessia Gazzola and Francesca Murer and Caterina Pozzan and Veronica Vanin and {Del Poggio}, Paolo and Stefano Olmi and Claudia Balsamo and Elena Vavassori and Luisa Benvegn{\`u} and Alberta Cappelli and Rita Golfieri and Cristina Mosconi and Matteo Renzulli and Giulia Bosco and Paola Roselli and Serena Dell'Isola and Lalungo, {Anna Maria} and Elena Rastrelli and Alessandro Moscatelli and Gaia Pellegatta and Antonino Picciotto and Vincenzo Savarino and Barcellona, {Maria Rosa} and Calogero Camm{\`a} and Giuseppe Cabibbo and Andrea Costantino and Roberto Virdone and Andrea Mega and Emanuele Rinninella and Valeria Mismas and Dall'Aglio, {Anna Chiara} and Valentina Feletti and Arianna Lanzi and Cappa, {Federica Mirici} and Elga Neri and Stefanini, {Giuseppe Francesco} and Stefano Tamberi and Elisabetta Biasini and Emanuela Porro and Maria Guarino and Baroni, {Gianluca Svegliati} and Laura Schiad{\`a} and Maria Chiaramonte and Fabiana Marchetti and Matteo Valerio",
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T1 - Years of life that could be saved from prevention of hepatocellular carcinoma

AU - Cucchetti, A.

AU - Trevisani, F.

AU - Bucci, L.

AU - Ravaioli, M.

AU - Farinati, F.

AU - Giannini, E. G.

AU - Ciccarese, F.

AU - Piscaglia, F.

AU - Rapaccini, G. L.

AU - Di Marco, M.

AU - Caturelli, E.

AU - Zoli, M.

AU - Borzio, F.

AU - Sacco, R.

AU - Maida, M.

AU - Felder, M.

AU - Morisco, F.

AU - Gasbarrini, A.

AU - Gemini, S.

AU - Foschi, F. G.

AU - Missale, G.

AU - Masotto, A.

AU - Affronti, A.

AU - Bernardi, M.

AU - Pinna, A. D.

AU - Bolondi, Luigi

AU - Biselli, Maurizio

AU - Caraceni, Paolo

AU - Domenicali, Marco

AU - Gramenzi, Annagiulia

AU - Magalotti, Donatella

AU - Pecorelli, Anna

AU - Serra, Carla

AU - Venerandi, Laura

AU - Gazzola, Alessia

AU - Murer, Francesca

AU - Pozzan, Caterina

AU - Vanin, Veronica

AU - Del Poggio, Paolo

AU - Olmi, Stefano

AU - Balsamo, Claudia

AU - Vavassori, Elena

AU - Benvegnù, Luisa

AU - Cappelli, Alberta

AU - Golfieri, Rita

AU - Mosconi, Cristina

AU - Renzulli, Matteo

AU - Bosco, Giulia

AU - Roselli, Paola

AU - Dell'Isola, Serena

AU - Lalungo, Anna Maria

AU - Rastrelli, Elena

AU - Moscatelli, Alessandro

AU - Pellegatta, Gaia

AU - Picciotto, Antonino

AU - Savarino, Vincenzo

AU - Barcellona, Maria Rosa

AU - Cammà, Calogero

AU - Cabibbo, Giuseppe

AU - Costantino, Andrea

AU - Virdone, Roberto

AU - Mega, Andrea

AU - Rinninella, Emanuele

AU - Mismas, Valeria

AU - Dall'Aglio, Anna Chiara

AU - Feletti, Valentina

AU - Lanzi, Arianna

AU - Cappa, Federica Mirici

AU - Neri, Elga

AU - Stefanini, Giuseppe Francesco

AU - Tamberi, Stefano

AU - Biasini, Elisabetta

AU - Porro, Emanuela

AU - Guarino, Maria

AU - Baroni, Gianluca Svegliati

AU - Schiadà, Laura

AU - Chiaramonte, Maria

AU - Marchetti, Fabiana

AU - Valerio, Matteo

PY - 2016/4/1

Y1 - 2016/4/1

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AB - Background: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim: To assess how many years of life are lost after HCC diagnosis. Methods: Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results: Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18-61 years) had the highest number of years-of-life lost, representing approximately 41% of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986-1999, to 10.7 in 2000-2006 and 7.4 years in 2007-2014. Currently, an HCC diagnosis when a single tumour

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