Years of life that could be saved from prevention of hepatocellular carcinoma

A. Cucchetti, F. Trevisani, L. Bucci, M. Ravaioli, F. Farinati, E. G. Giannini, F. Ciccarese, F. Piscaglia, G. L. Rapaccini, M. Di Marco, E. Caturelli, M. Zoli, F. Borzio, R. Sacco, M. Maida, M. Felder, F. Morisco, A. Gasbarrini, S. Gemini, F. G. FoschiG. Missale, A. Masotto, A. Affronti, M. Bernardi, A. D. Pinna, Luigi Bolondi, Maurizio Biselli, Paolo Caraceni, Marco Domenicali, Annagiulia Gramenzi, Donatella Magalotti, Anna Pecorelli, Carla Serra, Laura Venerandi, Alessia Gazzola, Francesca Murer, Caterina Pozzan, Veronica Vanin, Paolo Del Poggio, Stefano Olmi, Claudia Balsamo, Elena Vavassori, Luisa Benvegnù, Alberta Cappelli, Rita Golfieri, Cristina Mosconi, Matteo Renzulli, Giulia Bosco, Paola Roselli, Serena Dell'Isola, Anna Maria Lalungo, Elena Rastrelli, Alessandro Moscatelli, Gaia Pellegatta, Antonino Picciotto, Vincenzo Savarino, Maria Rosa Barcellona, Calogero Cammà, Giuseppe Cabibbo, Andrea Costantino, Roberto Virdone, Andrea Mega, Emanuele Rinninella, Valeria Mismas, Anna Chiara Dall'Aglio, Valentina Feletti, Arianna Lanzi, Federica Mirici Cappa, Elga Neri, Giuseppe Francesco Stefanini, Stefano Tamberi, Elisabetta Biasini, Emanuela Porro, Maria Guarino, Gianluca Svegliati Baroni, Laura Schiadà, Maria Chiaramonte, Fabiana Marchetti, Matteo Valerio

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim: To assess how many years of life are lost after HCC diagnosis. Methods: Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results: Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18-61 years) had the highest number of years-of-life lost, representing approximately 41% of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986-1999, to 10.7 in 2000-2006 and 7.4 years in 2007-2014. Currently, an HCC diagnosis when a single tumour

Original languageEnglish
Pages (from-to)814-824
Number of pages11
JournalAlimentary Pharmacology and Therapeutics
Volume43
Issue number7
DOIs
Publication statusPublished - Apr 1 2016

ASJC Scopus subject areas

  • Pharmacology (medical)

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