Yeast-like filamentous fungi: Molecular identification and in vitro susceptibility study

M.C. Esposto, A. Prigitano, G. Lo Cascio, C. Ossi, A. Grancini, C. Cavanna, F. Lallitto, M. Tejada, R. Bandettini, A. Mularoni, A.M. Tortorano

Research output: Contribution to journalArticlepeer-review

Abstract

Yeast-like filamentous fungi, collected in Italy from 1985 to 2018, were submitted to molecular identification and antifungal susceptibility testings. Clinical isolates were identified as Magnusiomyces capitatus (28), M. clavatus (18), and Geotrichum candidum (2). M. clavatus was prevalent among blood isolates (18/24), M. capitatus among isolates from other biological materials. The intrinsic echinocandin resistance was confirmed. Both species had low minimum inhibitory concentrations (MICs) of itraconazole, posaconazole, and voriconazole, while M. clavatus had lower MIC of flucytosine and higher MIC of isavuconazole than M. capitatus. The intrinsic resistance of these species to echinocandins could be the reason of the recent increase of M. clavatus bloodstream infections. © The Author(s) 2018. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.
Original languageEnglish
Pages (from-to)909-913
Number of pages5
JournalMedical Mycology
Volume57
Issue number7
DOIs
Publication statusPublished - 2019

Keywords

  • Geotrichum
  • Magnusiomyces
  • Saprochaete
  • fungemia
  • yeast-like filamentous fungi

Fingerprint Dive into the research topics of 'Yeast-like filamentous fungi: Molecular identification and in vitro susceptibility study'. Together they form a unique fingerprint.

Cite this