Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart

Shohei Ikeda, Risa Mukai, Wataru Mizushima, Peiyong Zhai, Shin-Ichi Oka, Michinari Nakamura, Dominic P Del Re, Sebastiano Sciarretta, Chiao-Po Hsu, Hiroaki Shimokawa, Junichi Sadoshima

Research output: Contribution to journalArticle

Abstract

Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in mediating the exacerbation of heart failure in response to pressure overload in the hearts of mice fed a high-fat diet. YAP induced dedifferentiation of cardiomyocytes through activation of transcriptional enhancer factor 1 (TEAD1), a transcription factor. Thus, YAP and TEAD1 are promising therapeutic targets for diabetic patients with high blood pressure to prevent the development of heart failure.

Original languageEnglish
Pages (from-to)611-622
Number of pages12
JournalJACC: Basic to Translational Science
Volume4
Issue number5
DOIs
Publication statusPublished - Sep 2019

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    Ikeda, S., Mukai, R., Mizushima, W., Zhai, P., Oka, S-I., Nakamura, M., Del Re, D. P., Sciarretta, S., Hsu, C-P., Shimokawa, H., & Sadoshima, J. (2019). Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart. JACC: Basic to Translational Science, 4(5), 611-622. https://doi.org/10.1016/j.jacbts.2019.05.006