Yield of prolonged wireless pH monitoring in achalasia patients successfully treated with pneumatic dilation

Aurelio Mauro, Marianna Franchina, Alessandra Elvevi, Delia Pugliese, Andrea Tenca, Dario Conte, Roberto Penagini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Gastro-oesophageal reflux disease (GORD) is a long-term complication of achalasia treatments. The aim of our study was to evaluate the yield of prolonged wireless pH monitoring in patients with successfully treated achalasia and its influence on proton pump inhibitor (PPI) use. Methods: Twenty-five patients with achalasia who underwent prolonged wireless pH monitoring after a successful treatment with pneumatic dilation were enrolled. pH variables were analysed in the first 24 hours of monitoring to determine if tracings were indicative of GORD; the same variables were analysed in the following 24-hour period in order to obtain a worst-day diagnosis of GORD. PPI therapy before and after the test was recorded. Results: Five out of 25 patients had GORD diagnosis during the first day of monitoring and four of them had oesophagitis at endoscopy. During the following days of monitoring four more patients had a diagnosis of GORD. Out of the 25 patients, PPIs were started after the test in six asymptomatic GORD-positive ones, whereas prescription of PPIs was stopped without detrimental effect on symptoms in three GORD-negative patients. Conclusions: Prolonged wireless pH monitoring is a useful test to be added to endoscopy in order to evaluate GORD and to optimise antisecretory treatment in successfully treated achalasia patients.

Original languageEnglish
Pages (from-to)789-795
Number of pages7
JournalUnited European Gastroenterology Journal
Volume5
Issue number6
DOIs
Publication statusPublished - Oct 1 2017

Keywords

  • achalasia
  • gastro-oesophageal reflux disease
  • oesophagus
  • pH-metry
  • Prolonged wireless pH monitoring

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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