Yin-Yang strands of PCAF/Hedgehog axis in cancer control

Paola Infante, Gianluca Canettieri, Alberto Gulino, Lucia Di Marcotullio

Research output: Contribution to journalArticlepeer-review

Abstract

PCAF (p300/CBP associated factor) harbors acetyltransferase and a recently identified ubiquitylation activity that regulates gene expression in response to genotoxic stress or mitogenic signals. We highlight the dual role of PCAF in the control of Hedgehog signaling, a master regulator of tissue development, stemness, and tumorigenesis. By promoting histone acetylation at Hedgehog/GLI1 target gene promoters or direct ubiquitylation and proteolysis of GLI1, the PCAF/GLI1 axis stands as a promising therapeutic target for Hedgehog-dependent tumors.

Original languageEnglish
Pages (from-to)416-418
Number of pages3
JournalTrends in Molecular Medicine
Volume20
Issue number8
DOIs
Publication statusPublished - 2014

Keywords

  • Acetyltransferase
  • Cancer
  • E3-ubiquitin ligase
  • Hedgehog
  • P53
  • PCAF

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Medicine(all)

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