Young-onset and late-onset Parkinson's disease exhibit a different profile of fluid biomarkers and clinical features

Tommaso Schirinzi, Giulia Di Lazzaro, Giulia Maria Sancesario, Susanna Summa, Simona Petrucci, Vito Luigi Colona, Sergio Bernardini, Mariangela Pierantozzi, Alessandro Stefani, Nicola Biagio Mercuri, Antonio Pisani

Research output: Contribution to journalArticlepeer-review


Young-onset Parkinson's disease (YOPD) is a relevant condition whose neurobiology is questioned if different from those of typical late-onset Parkinson's disease (LOPD). Here, we explored whether the clinical-biochemical profile of Parkinson's disease (PD) could be affected by the age-of-onset (AO), as a possible result of a distinct neurodegenerative process. A panel of fluid biomarkers (CSF lactate, 42-amyloid-β peptide, total and 181-phosphorylated tau; serum uric acid) and the standard scores for motor and nonmotor signs were assessed in 76 idiopathic PD patients (genetic cases excluded; YOPD, AO ≤ 50, n = 44; LOPD, AO > 50, n = 32) and 75 sex/age-matched controls, adjusting the models for the main confounding factors. In PD, AO directly correlated to either CSF lactate and tau proteins or the nonmotor symptoms scale score. Specifically, a younger AO was associated with lower levels of biomarkers and minor burden of nonmotor symptoms. Our findings indicate that clinical-biochemical features of idiopathic PD may vary depending on the AO, accounting for different profiles in YOPD and LOPD whose recognition is fundamental for further pathophysiological implications and clinical applications.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalNeurobiology of Aging
Publication statusPublished - Jun 2020


  • Aging
  • Early-onset Parkinson's disease
  • Fluid biomarkers
  • Late-onset Parkinson's disease
  • Young-onset Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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