Young-onset and late-onset Parkinson's disease exhibit a different profile of fluid biomarkers and clinical features: Neurobiology of Aging

T. Schirinzi, G. Di Lazzaro, G.M. Sancesario, S. Summa, S. Petrucci, V.L. Colona, S. Bernardini, M. Pierantozzi, A. Stefani, N.B. Mercuri, A. Pisani

Research output: Contribution to journalArticlepeer-review


Young-onset Parkinson's disease (YOPD) is a relevant condition whose neurobiology is questioned if different from those of typical late-onset Parkinson's disease (LOPD). Here, we explored whether the clinical-biochemical profile of Parkinson's disease (PD) could be affected by the age-of-onset (AO), as a possible result of a distinct neurodegenerative process. A panel of fluid biomarkers (CSF lactate, 42-amyloid-β peptide, total and 181-phosphorylated tau; serum uric acid) and the standard scores for motor and nonmotor signs were assessed in 76 idiopathic PD patients (genetic cases excluded; YOPD, AO ≤ 50, n = 44; LOPD, AO > 50, n = 32) and 75 sex/age-matched controls, adjusting the models for the main confounding factors. In PD, AO directly correlated to either CSF lactate and tau proteins or the nonmotor symptoms scale score. Specifically, a younger AO was associated with lower levels of biomarkers and minor burden of nonmotor symptoms. Our findings indicate that clinical-biochemical features of idiopathic PD may vary depending on the AO, accounting for different profiles in YOPD and LOPD whose recognition is fundamental for further pathophysiological implications and clinical applications. © 2020 Elsevier Inc.
Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalNeurobiol. Aging
Publication statusPublished - 2020


  • Aging
  • Early-onset Parkinson's disease
  • Fluid biomarkers
  • Late-onset Parkinson's disease
  • Young-onset Parkinson's disease
  • amyloid beta protein[1-42]
  • antiparkinson agent
  • lactic acid
  • tau protein
  • uric acid
  • amyloid beta protein
  • amyloid beta-protein (1-42)
  • biological marker
  • peptide fragment
  • adult
  • age distribution
  • aged
  • Article
  • clinical feature
  • controlled study
  • female
  • human
  • late onset Parkinson disease
  • major clinical study
  • male
  • Mini Mental State Examination
  • onset age
  • Parkinson disease
  • priority journal
  • protein cerebrospinal fluid level
  • sex ratio
  • uric acid blood level
  • young onset Parkinson disease
  • age
  • blood
  • cerebrospinal fluid
  • metabolism
  • middle aged
  • pathology
  • pathophysiology
  • personalized medicine
  • Adult
  • Age Factors
  • Age of Onset
  • Aged
  • Amyloid beta-Peptides
  • Biomarkers
  • Humans
  • Lactates
  • Middle Aged
  • Parkinson Disease
  • Peptide Fragments
  • Precision Medicine
  • tau Proteins
  • Uric Acid


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