Abstract
Young-onset Parkinson's disease (YOPD) is a relevant condition whose neurobiology is questioned if different from those of typical late-onset Parkinson's disease (LOPD). Here, we explored whether the clinical-biochemical profile of Parkinson's disease (PD) could be affected by the age-of-onset (AO), as a possible result of a distinct neurodegenerative process. A panel of fluid biomarkers (CSF lactate, 42-amyloid-β peptide, total and 181-phosphorylated tau; serum uric acid) and the standard scores for motor and nonmotor signs were assessed in 76 idiopathic PD patients (genetic cases excluded; YOPD, AO ≤ 50, n = 44; LOPD, AO > 50, n = 32) and 75 sex/age-matched controls, adjusting the models for the main confounding factors. In PD, AO directly correlated to either CSF lactate and tau proteins or the nonmotor symptoms scale score. Specifically, a younger AO was associated with lower levels of biomarkers and minor burden of nonmotor symptoms. Our findings indicate that clinical-biochemical features of idiopathic PD may vary depending on the AO, accounting for different profiles in YOPD and LOPD whose recognition is fundamental for further pathophysiological implications and clinical applications. © 2020 Elsevier Inc.
Original language | English |
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Pages (from-to) | 119-124 |
Number of pages | 6 |
Journal | Neurobiol. Aging |
Volume | 90 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- Aging
- Early-onset Parkinson's disease
- Fluid biomarkers
- Late-onset Parkinson's disease
- Young-onset Parkinson's disease
- amyloid beta protein[1-42]
- antiparkinson agent
- lactic acid
- tau protein
- uric acid
- amyloid beta protein
- amyloid beta-protein (1-42)
- biological marker
- peptide fragment
- adult
- age distribution
- aged
- Article
- clinical feature
- controlled study
- female
- human
- late onset Parkinson disease
- major clinical study
- male
- Mini Mental State Examination
- onset age
- Parkinson disease
- priority journal
- protein cerebrospinal fluid level
- sex ratio
- uric acid blood level
- young onset Parkinson disease
- age
- blood
- cerebrospinal fluid
- metabolism
- middle aged
- pathology
- pathophysiology
- personalized medicine
- Adult
- Age Factors
- Age of Onset
- Aged
- Amyloid beta-Peptides
- Biomarkers
- Humans
- Lactates
- Middle Aged
- Parkinson Disease
- Peptide Fragments
- Precision Medicine
- tau Proteins
- Uric Acid