Younger age at diagnosis of type 1 diabetes mellitus in children of immigrated families born in Italy

Francesco Cadario, A. Vercellotti, M. Trada, M. Zaffaroni, A. Rapa, D. Iafusco, S. Salardi, R. Baldelli, G. Bona, S. Rigardo, R. Lera, V. Cherubini, S. Francolini, A. Fifi, A. Scaramuzza, L. Cavallo, S. Zucchini, E. Corbelli, F. Gallo, M. A. Zedda & 55 others E. Angius, C. Ripoli, A. La Loggia, G. Scalia, M. Cicchetti, A. Macchiaroli, F. Oteri, M. Pocecco, G. Cerasoli, D. Sperlì, M. Montaldo, L. Startari, A. Vergerio, P. Banin, M. Martinucci, S. Toni, C. Mastrangelo, R. Lorini, G. D'Annunzio, M. Cotellessa, L. Minicucci, M. Pescarmona, M. Di Quinci, F. Lombardo, L. Iughetti, B. Predieri, S. Boccato, F. Prisco, C. Mongiotti, F. Cardella, M. Vanelli, G. Chiari, P. Zanasi, D. Larizza, A. Borghesi, G. De Giorgi, L. Calisti, S. Menchini, A. Marsciani, L. Pausini, P. Patera, A. Crinò, F. Cerutti, C. Sacchetti, I. Rabbone, F. Fontana, R. Giorgetti, G. Trussi, V. Cauvin, L. Gargantini, A. Tenore, M. Zanatta, A. Salvatoni, M. Fusari, C. Araldi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The aim of this study was to evaluate the age of immigrants' children at diagnosis of Type 1 diabetes (T1DM) according to their country of birth. Immigration from developing countries to a westernised area causes rapid changes in the environmental conditions, and we investigated whether the location of birth, either inside or outside Italy, is associated with age at diagnosis of diabetes. Out of a prevalent hospital-based cohort of 5718 T1DM children cared for in 2002 in 47 Italian Pediatric Diabetes Units, we recruited 195 children (M: 97) of immigrants from developing countries - 119 were born in Italy and 76 outside the European Union. Children with only one immigrant parent (no. 42) were also included. Age at diagnosis of T1DM, and other variables were compared with those of Italian children. Children of immigrated families born in Italy developed T1DM at a median age of 4.0 yr (IQR 2.2-6.9), whereas those born in developing countries and that had immigrated to Italy after birth developed T1DM at a median age of 7.9 yr (IQR 5.1-10.7, p

Original languageEnglish
Pages (from-to)913-918
Number of pages6
JournalJournal of Endocrinological Investigation
Volume27
Issue number10
Publication statusPublished - Nov 2004

Fingerprint

Type 1 Diabetes Mellitus
Italy
Developing Countries
Parturition
Emigration and Immigration
European Union
Pediatrics

Keywords

  • Accelerator hypothesis
  • Developing countries
  • Hygiene hypothesis
  • Immigration
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology

Cite this

Cadario, F., Vercellotti, A., Trada, M., Zaffaroni, M., Rapa, A., Iafusco, D., ... Araldi, C. (2004). Younger age at diagnosis of type 1 diabetes mellitus in children of immigrated families born in Italy. Journal of Endocrinological Investigation, 27(10), 913-918.

Younger age at diagnosis of type 1 diabetes mellitus in children of immigrated families born in Italy. / Cadario, Francesco; Vercellotti, A.; Trada, M.; Zaffaroni, M.; Rapa, A.; Iafusco, D.; Salardi, S.; Baldelli, R.; Bona, G.; Rigardo, S.; Lera, R.; Cherubini, V.; Francolini, S.; Fifi, A.; Scaramuzza, A.; Cavallo, L.; Zucchini, S.; Corbelli, E.; Gallo, F.; Zedda, M. A.; Angius, E.; Ripoli, C.; La Loggia, A.; Scalia, G.; Cicchetti, M.; Macchiaroli, A.; Oteri, F.; Pocecco, M.; Cerasoli, G.; Sperlì, D.; Montaldo, M.; Startari, L.; Vergerio, A.; Banin, P.; Martinucci, M.; Toni, S.; Mastrangelo, C.; Lorini, R.; D'Annunzio, G.; Cotellessa, M.; Minicucci, L.; Pescarmona, M.; Di Quinci, M.; Lombardo, F.; Iughetti, L.; Predieri, B.; Boccato, S.; Prisco, F.; Mongiotti, C.; Cardella, F.; Vanelli, M.; Chiari, G.; Zanasi, P.; Larizza, D.; Borghesi, A.; De Giorgi, G.; Calisti, L.; Menchini, S.; Marsciani, A.; Pausini, L.; Patera, P.; Crinò, A.; Cerutti, F.; Sacchetti, C.; Rabbone, I.; Fontana, F.; Giorgetti, R.; Trussi, G.; Cauvin, V.; Gargantini, L.; Tenore, A.; Zanatta, M.; Salvatoni, A.; Fusari, M.; Araldi, C.

In: Journal of Endocrinological Investigation, Vol. 27, No. 10, 11.2004, p. 913-918.

Research output: Contribution to journalArticle

Cadario, F, Vercellotti, A, Trada, M, Zaffaroni, M, Rapa, A, Iafusco, D, Salardi, S, Baldelli, R, Bona, G, Rigardo, S, Lera, R, Cherubini, V, Francolini, S, Fifi, A, Scaramuzza, A, Cavallo, L, Zucchini, S, Corbelli, E, Gallo, F, Zedda, MA, Angius, E, Ripoli, C, La Loggia, A, Scalia, G, Cicchetti, M, Macchiaroli, A, Oteri, F, Pocecco, M, Cerasoli, G, Sperlì, D, Montaldo, M, Startari, L, Vergerio, A, Banin, P, Martinucci, M, Toni, S, Mastrangelo, C, Lorini, R, D'Annunzio, G, Cotellessa, M, Minicucci, L, Pescarmona, M, Di Quinci, M, Lombardo, F, Iughetti, L, Predieri, B, Boccato, S, Prisco, F, Mongiotti, C, Cardella, F, Vanelli, M, Chiari, G, Zanasi, P, Larizza, D, Borghesi, A, De Giorgi, G, Calisti, L, Menchini, S, Marsciani, A, Pausini, L, Patera, P, Crinò, A, Cerutti, F, Sacchetti, C, Rabbone, I, Fontana, F, Giorgetti, R, Trussi, G, Cauvin, V, Gargantini, L, Tenore, A, Zanatta, M, Salvatoni, A, Fusari, M & Araldi, C 2004, 'Younger age at diagnosis of type 1 diabetes mellitus in children of immigrated families born in Italy', Journal of Endocrinological Investigation, vol. 27, no. 10, pp. 913-918.
Cadario F, Vercellotti A, Trada M, Zaffaroni M, Rapa A, Iafusco D et al. Younger age at diagnosis of type 1 diabetes mellitus in children of immigrated families born in Italy. Journal of Endocrinological Investigation. 2004 Nov;27(10):913-918.
Cadario, Francesco ; Vercellotti, A. ; Trada, M. ; Zaffaroni, M. ; Rapa, A. ; Iafusco, D. ; Salardi, S. ; Baldelli, R. ; Bona, G. ; Rigardo, S. ; Lera, R. ; Cherubini, V. ; Francolini, S. ; Fifi, A. ; Scaramuzza, A. ; Cavallo, L. ; Zucchini, S. ; Corbelli, E. ; Gallo, F. ; Zedda, M. A. ; Angius, E. ; Ripoli, C. ; La Loggia, A. ; Scalia, G. ; Cicchetti, M. ; Macchiaroli, A. ; Oteri, F. ; Pocecco, M. ; Cerasoli, G. ; Sperlì, D. ; Montaldo, M. ; Startari, L. ; Vergerio, A. ; Banin, P. ; Martinucci, M. ; Toni, S. ; Mastrangelo, C. ; Lorini, R. ; D'Annunzio, G. ; Cotellessa, M. ; Minicucci, L. ; Pescarmona, M. ; Di Quinci, M. ; Lombardo, F. ; Iughetti, L. ; Predieri, B. ; Boccato, S. ; Prisco, F. ; Mongiotti, C. ; Cardella, F. ; Vanelli, M. ; Chiari, G. ; Zanasi, P. ; Larizza, D. ; Borghesi, A. ; De Giorgi, G. ; Calisti, L. ; Menchini, S. ; Marsciani, A. ; Pausini, L. ; Patera, P. ; Crinò, A. ; Cerutti, F. ; Sacchetti, C. ; Rabbone, I. ; Fontana, F. ; Giorgetti, R. ; Trussi, G. ; Cauvin, V. ; Gargantini, L. ; Tenore, A. ; Zanatta, M. ; Salvatoni, A. ; Fusari, M. ; Araldi, C. / Younger age at diagnosis of type 1 diabetes mellitus in children of immigrated families born in Italy. In: Journal of Endocrinological Investigation. 2004 ; Vol. 27, No. 10. pp. 913-918.
@article{6d83c5ee843e48c085639bcfb54c0579,
title = "Younger age at diagnosis of type 1 diabetes mellitus in children of immigrated families born in Italy",
abstract = "The aim of this study was to evaluate the age of immigrants' children at diagnosis of Type 1 diabetes (T1DM) according to their country of birth. Immigration from developing countries to a westernised area causes rapid changes in the environmental conditions, and we investigated whether the location of birth, either inside or outside Italy, is associated with age at diagnosis of diabetes. Out of a prevalent hospital-based cohort of 5718 T1DM children cared for in 2002 in 47 Italian Pediatric Diabetes Units, we recruited 195 children (M: 97) of immigrants from developing countries - 119 were born in Italy and 76 outside the European Union. Children with only one immigrant parent (no. 42) were also included. Age at diagnosis of T1DM, and other variables were compared with those of Italian children. Children of immigrated families born in Italy developed T1DM at a median age of 4.0 yr (IQR 2.2-6.9), whereas those born in developing countries and that had immigrated to Italy after birth developed T1DM at a median age of 7.9 yr (IQR 5.1-10.7, p",
keywords = "Accelerator hypothesis, Developing countries, Hygiene hypothesis, Immigration, Type 1 diabetes",
author = "Francesco Cadario and A. Vercellotti and M. Trada and M. Zaffaroni and A. Rapa and D. Iafusco and S. Salardi and R. Baldelli and G. Bona and S. Rigardo and R. Lera and V. Cherubini and S. Francolini and A. Fifi and A. Scaramuzza and L. Cavallo and S. Zucchini and E. Corbelli and F. Gallo and Zedda, {M. A.} and E. Angius and C. Ripoli and {La Loggia}, A. and G. Scalia and M. Cicchetti and A. Macchiaroli and F. Oteri and M. Pocecco and G. Cerasoli and D. Sperl{\`i} and M. Montaldo and L. Startari and A. Vergerio and P. Banin and M. Martinucci and S. Toni and C. Mastrangelo and R. Lorini and G. D'Annunzio and M. Cotellessa and L. Minicucci and M. Pescarmona and {Di Quinci}, M. and F. Lombardo and L. Iughetti and B. Predieri and S. Boccato and F. Prisco and C. Mongiotti and F. Cardella and M. Vanelli and G. Chiari and P. Zanasi and D. Larizza and A. Borghesi and {De Giorgi}, G. and L. Calisti and S. Menchini and A. Marsciani and L. Pausini and P. Patera and A. Crin{\`o} and F. Cerutti and C. Sacchetti and I. Rabbone and F. Fontana and R. Giorgetti and G. Trussi and V. Cauvin and L. Gargantini and A. Tenore and M. Zanatta and A. Salvatoni and M. Fusari and C. Araldi",
year = "2004",
month = "11",
language = "English",
volume = "27",
pages = "913--918",
journal = "Journal of Endocrinological Investigation",
issn = "0391-4097",
publisher = "Springer International Publishing",
number = "10",

}

TY - JOUR

T1 - Younger age at diagnosis of type 1 diabetes mellitus in children of immigrated families born in Italy

AU - Cadario, Francesco

AU - Vercellotti, A.

AU - Trada, M.

AU - Zaffaroni, M.

AU - Rapa, A.

AU - Iafusco, D.

AU - Salardi, S.

AU - Baldelli, R.

AU - Bona, G.

AU - Rigardo, S.

AU - Lera, R.

AU - Cherubini, V.

AU - Francolini, S.

AU - Fifi, A.

AU - Scaramuzza, A.

AU - Cavallo, L.

AU - Zucchini, S.

AU - Corbelli, E.

AU - Gallo, F.

AU - Zedda, M. A.

AU - Angius, E.

AU - Ripoli, C.

AU - La Loggia, A.

AU - Scalia, G.

AU - Cicchetti, M.

AU - Macchiaroli, A.

AU - Oteri, F.

AU - Pocecco, M.

AU - Cerasoli, G.

AU - Sperlì, D.

AU - Montaldo, M.

AU - Startari, L.

AU - Vergerio, A.

AU - Banin, P.

AU - Martinucci, M.

AU - Toni, S.

AU - Mastrangelo, C.

AU - Lorini, R.

AU - D'Annunzio, G.

AU - Cotellessa, M.

AU - Minicucci, L.

AU - Pescarmona, M.

AU - Di Quinci, M.

AU - Lombardo, F.

AU - Iughetti, L.

AU - Predieri, B.

AU - Boccato, S.

AU - Prisco, F.

AU - Mongiotti, C.

AU - Cardella, F.

AU - Vanelli, M.

AU - Chiari, G.

AU - Zanasi, P.

AU - Larizza, D.

AU - Borghesi, A.

AU - De Giorgi, G.

AU - Calisti, L.

AU - Menchini, S.

AU - Marsciani, A.

AU - Pausini, L.

AU - Patera, P.

AU - Crinò, A.

AU - Cerutti, F.

AU - Sacchetti, C.

AU - Rabbone, I.

AU - Fontana, F.

AU - Giorgetti, R.

AU - Trussi, G.

AU - Cauvin, V.

AU - Gargantini, L.

AU - Tenore, A.

AU - Zanatta, M.

AU - Salvatoni, A.

AU - Fusari, M.

AU - Araldi, C.

PY - 2004/11

Y1 - 2004/11

N2 - The aim of this study was to evaluate the age of immigrants' children at diagnosis of Type 1 diabetes (T1DM) according to their country of birth. Immigration from developing countries to a westernised area causes rapid changes in the environmental conditions, and we investigated whether the location of birth, either inside or outside Italy, is associated with age at diagnosis of diabetes. Out of a prevalent hospital-based cohort of 5718 T1DM children cared for in 2002 in 47 Italian Pediatric Diabetes Units, we recruited 195 children (M: 97) of immigrants from developing countries - 119 were born in Italy and 76 outside the European Union. Children with only one immigrant parent (no. 42) were also included. Age at diagnosis of T1DM, and other variables were compared with those of Italian children. Children of immigrated families born in Italy developed T1DM at a median age of 4.0 yr (IQR 2.2-6.9), whereas those born in developing countries and that had immigrated to Italy after birth developed T1DM at a median age of 7.9 yr (IQR 5.1-10.7, p

AB - The aim of this study was to evaluate the age of immigrants' children at diagnosis of Type 1 diabetes (T1DM) according to their country of birth. Immigration from developing countries to a westernised area causes rapid changes in the environmental conditions, and we investigated whether the location of birth, either inside or outside Italy, is associated with age at diagnosis of diabetes. Out of a prevalent hospital-based cohort of 5718 T1DM children cared for in 2002 in 47 Italian Pediatric Diabetes Units, we recruited 195 children (M: 97) of immigrants from developing countries - 119 were born in Italy and 76 outside the European Union. Children with only one immigrant parent (no. 42) were also included. Age at diagnosis of T1DM, and other variables were compared with those of Italian children. Children of immigrated families born in Italy developed T1DM at a median age of 4.0 yr (IQR 2.2-6.9), whereas those born in developing countries and that had immigrated to Italy after birth developed T1DM at a median age of 7.9 yr (IQR 5.1-10.7, p

KW - Accelerator hypothesis

KW - Developing countries

KW - Hygiene hypothesis

KW - Immigration

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=19944425996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19944425996&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 913

EP - 918

JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

SN - 0391-4097

IS - 10

ER -