Y3+ embedded in polymeric nanoparticles: Morphology, dimension and stability of composite colloidal system

I. Venditti, A. Cartoni, L. Fontana, G. Testa, F. A. Scaramuzzo, R. Faccini, C. Mancini Terracciano, E. Solfaroli Camillocci, S. Morganti, A. Giordano, T. Scotognella, D. Rotili, V. Dini, F. Marini, I. Fratoddi

Research output: Contribution to journalArticle

Abstract

Radiolabeled nanoparticles are promising tools in cancer diagnosis and therapy. Moreover, yttrium-90 (90Y) is a good candidate as suitable β emitting radioisotope for a new approach to radio-guided surgery (RGS) proposed by some researchers of our group. In this work, we developed new composite nanoparticles, based on polymethylmethacrylate (PMMA), and poly(methylmethacrylate-co-acrylic acid), P(MMA/AA), embedded with yttrium ion (89Y3+), as a first step for the development of new 90Y3+ based nanocomposites. The composite nanoparticles were synthesised by emulsion polymerization technique, in the presence of potassium persulfate (KPS) as radical initiator, toluene as cosolvent, diethylenetriamine penta acetic acid dianhydride (DTPA) as chelating agent, using different MMA/89Y3+ molar ratios. The yttrium doped polymeric nanoparticles were characterized by means of FTIR spectroscopy, SEM-EDX, AFM, and DLS measurements. The influence of experimental parameters, such as cosolvent and reaction time, on morphology and dimension of composite nanoparticles was investigated, and monodispersed nanospheres with diameters from 20 nm to 400 nm were obtained. The composite material was purified and studied by means of DLS to confirm the colloid stability in water solution at different temperatures (25 °C and 37 °C) up to 3 weeks.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume532
DOIs
Publication statusPublished - Nov 5 2017

Keywords

  • Nanostructured composites
  • Polymeric nanoparticles
  • Polymethylmethacrylate
  • Radiolabeled nanoparticles
  • Yttrium

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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    Venditti, I., Cartoni, A., Fontana, L., Testa, G., Scaramuzzo, F. A., Faccini, R., Terracciano, C. M., Camillocci, E. S., Morganti, S., Giordano, A., Scotognella, T., Rotili, D., Dini, V., Marini, F., & Fratoddi, I. (2017). Y3+ embedded in polymeric nanoparticles: Morphology, dimension and stability of composite colloidal system. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 532, 125-131. https://doi.org/10.1016/j.colsurfa.2017.05.082