Zika virus replication in dorsal root ganglia explants from interferon receptor1 knockout mice causes myelin degeneration

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Abstract

Zika virus (ZIKV) is a neurotropic agent that targets the developing fetal brain in women infected during pregnancy. In addition to the developing central nervous system, ZIKV has been recently shown to infect cells of the peripheral nervous system (PNS), highlighting its potential to cause acute peripheral neuropathies in adults, such as Guillain-Barré Syndrome (GBS). Here we show that myelinating dorsal root ganglia (DRG) explants obtained from interferon-alpha/beta receptor knock-out mice are productively infected by ZIKV. Virus replication is cytopathic in both peripheral neurons and myelinating Schwann cells leading to myelin disruption. These results confirm and extend previous observations suggesting that the PNS is indeed a potential site of ZIKV infection, replication and cytopathicity. © 2018 The Author(s).
Original languageEnglish
Article number10166
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 2018

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Spinal Ganglia
Virus Replication
Myelin Sheath
Knockout Mice
Interferons
Peripheral Nervous System
Interferon alpha-beta Receptor
Schwann Cells
Peripheral Nervous System Diseases
Central Nervous System
Neurons
Pregnancy
Brain
Zika Virus

Cite this

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title = "Zika virus replication in dorsal root ganglia explants from interferon receptor1 knockout mice causes myelin degeneration",
abstract = "Zika virus (ZIKV) is a neurotropic agent that targets the developing fetal brain in women infected during pregnancy. In addition to the developing central nervous system, ZIKV has been recently shown to infect cells of the peripheral nervous system (PNS), highlighting its potential to cause acute peripheral neuropathies in adults, such as Guillain-Barr{\'e} Syndrome (GBS). Here we show that myelinating dorsal root ganglia (DRG) explants obtained from interferon-alpha/beta receptor knock-out mice are productively infected by ZIKV. Virus replication is cytopathic in both peripheral neurons and myelinating Schwann cells leading to myelin disruption. These results confirm and extend previous observations suggesting that the PNS is indeed a potential site of ZIKV infection, replication and cytopathicity. {\circledC} 2018 The Author(s).",
author = "VG Volpi and I Pagani and S Ghezzi and M Iannacone and M D'antonio and E Vicenzi",
year = "2018",
doi = "10.1038/s41598-018-28257-5",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

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TY - JOUR

T1 - Zika virus replication in dorsal root ganglia explants from interferon receptor1 knockout mice causes myelin degeneration

AU - Volpi, VG

AU - Pagani, I

AU - Ghezzi, S

AU - Iannacone, M

AU - D'antonio, M

AU - Vicenzi, E

PY - 2018

Y1 - 2018

N2 - Zika virus (ZIKV) is a neurotropic agent that targets the developing fetal brain in women infected during pregnancy. In addition to the developing central nervous system, ZIKV has been recently shown to infect cells of the peripheral nervous system (PNS), highlighting its potential to cause acute peripheral neuropathies in adults, such as Guillain-Barré Syndrome (GBS). Here we show that myelinating dorsal root ganglia (DRG) explants obtained from interferon-alpha/beta receptor knock-out mice are productively infected by ZIKV. Virus replication is cytopathic in both peripheral neurons and myelinating Schwann cells leading to myelin disruption. These results confirm and extend previous observations suggesting that the PNS is indeed a potential site of ZIKV infection, replication and cytopathicity. © 2018 The Author(s).

AB - Zika virus (ZIKV) is a neurotropic agent that targets the developing fetal brain in women infected during pregnancy. In addition to the developing central nervous system, ZIKV has been recently shown to infect cells of the peripheral nervous system (PNS), highlighting its potential to cause acute peripheral neuropathies in adults, such as Guillain-Barré Syndrome (GBS). Here we show that myelinating dorsal root ganglia (DRG) explants obtained from interferon-alpha/beta receptor knock-out mice are productively infected by ZIKV. Virus replication is cytopathic in both peripheral neurons and myelinating Schwann cells leading to myelin disruption. These results confirm and extend previous observations suggesting that the PNS is indeed a potential site of ZIKV infection, replication and cytopathicity. © 2018 The Author(s).

U2 - 10.1038/s41598-018-28257-5

DO - 10.1038/s41598-018-28257-5

M3 - Article

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 10166

ER -