TY - JOUR
T1 - ZIKV infection induces an inflammatory response but fails to activate types I, II, and III IFN response in human PBMC
AU - Colavita, Francesca
AU - Bordoni, Veronica
AU - Caglioti, Claudia
AU - Biava, Mirella
AU - Castilletti, Concetta
AU - Bordi, Licia
AU - Quartu, Serena
AU - Iannetta, Marco
AU - Ippolito, Giuseppe
AU - Agrati, Chiara
AU - Capobianchi, Maria Rosaria
AU - Lalle, Eleonora
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The recent epidemic in the Americas caused by Zika virus (ZIKV), Asian lineage, spurred the research towards a better understanding of how ZIKV infection affects the host immune response. The aim of this study was to evaluate the effects of Asian and East African ZIKV strain infection on the induction of IFN and proinflammatory and Th2 cytokines in human PBMC. We reported a slight modulation of type II IFN in PBMC exposed to Asian strain, but not to African strain, and a complete lack of type I and III IFN induction by both strains, suggesting the ability of ZIKV to evade the IFN system not only inhibiting the antiviral IFN response but also IFN production. Moreover, we highlighted a polyfunctional immune activation only in PBMC exposed to Asian strain, due to the induction of an inflammatory profile (IL-6, IL-8) and of a Th9 (IL-9) response. Overall, our data show a different ability of the ZIKV Asian strain, with respect to the African strain, to activate host immune response that may have pathogenetic implications for virus spread in vivo, including mother-to-child transmission and induction of severe fetal complications, as birth defects and neurological disorders.
AB - The recent epidemic in the Americas caused by Zika virus (ZIKV), Asian lineage, spurred the research towards a better understanding of how ZIKV infection affects the host immune response. The aim of this study was to evaluate the effects of Asian and East African ZIKV strain infection on the induction of IFN and proinflammatory and Th2 cytokines in human PBMC. We reported a slight modulation of type II IFN in PBMC exposed to Asian strain, but not to African strain, and a complete lack of type I and III IFN induction by both strains, suggesting the ability of ZIKV to evade the IFN system not only inhibiting the antiviral IFN response but also IFN production. Moreover, we highlighted a polyfunctional immune activation only in PBMC exposed to Asian strain, due to the induction of an inflammatory profile (IL-6, IL-8) and of a Th9 (IL-9) response. Overall, our data show a different ability of the ZIKV Asian strain, with respect to the African strain, to activate host immune response that may have pathogenetic implications for virus spread in vivo, including mother-to-child transmission and induction of severe fetal complications, as birth defects and neurological disorders.
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U2 - 10.1155/2018/2450540
DO - 10.1155/2018/2450540
M3 - Article
AN - SCOPUS:85055031873
VL - 2018
JO - Mediators of Inflammation
JF - Mediators of Inflammation
SN - 0962-9351
M1 - 2450540
ER -