Zinc and COVID-19: Basis of Current Clinical Trials

Amit Pal; Rosanna Squitti; Mario Picozza; Anil Pawar; Mauro Rongioletti; Atanu Kumar Dutta; Sibasish Sahoo; Kalyan Goswami; Praveen Sharma; Rajendra Prasad

doi:10.1007/s12011-020-02437-9

Zinc and COVID-19: Basis of Current Clinical Trials

Amit Pal, Rosanna Squitti, Mario Picozza, Anil Pawar, Mauro Rongioletti, Atanu Kumar Dutta, Sibasish Sahoo, Kalyan Goswami, Praveen Sharma, Rajendra Prasad

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Review article › peer-review

Abstract

Coronavirus disease-2019 (COVID-19) pandemic continues to threaten patients, societies, and economic and healthcare systems around the world. Like many other diseases, the host immune system determines the progress of COVID-19 and fatality. Modulation of inflammatory response and cytokine production using immunonutrition is a novel concept that has been applied to other diseases as well. Zinc, one of the anti-inflammatory and antioxidant micronutrient found in food with well-established role in immunity, is currently being used in some clinical trials against COVID-19. This review integrates the contemporary studies of role of zinc in antiviral immunity along with discussing its potential role against COVID-19, and ongoing COVID-19 clinical trials using zinc.

Original language	English
Number of pages	11
Journal	Biological Trace Element Research
DOIs	https://doi.org/10.1007/s12011-020-02437-9
Publication status	E-pub ahead of print - Nov 22 2020

Keywords

Clinical trials
COVID-19
Immunity
Zinc

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Clinical Biochemistry
Biochemistry, medical
Inorganic Chemistry

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10.1007/s12011-020-02437-9

Cite this

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abstract = "Coronavirus disease-2019 (COVID-19) pandemic continues to threaten patients, societies, and economic and healthcare systems around the world. Like many other diseases, the host immune system determines the progress of COVID-19 and fatality. Modulation of inflammatory response and cytokine production using immunonutrition is a novel concept that has been applied to other diseases as well. Zinc, one of the anti-inflammatory and antioxidant micronutrient found in food with well-established role in immunity, is currently being used in some clinical trials against COVID-19. This review integrates the contemporary studies of role of zinc in antiviral immunity along with discussing its potential role against COVID-19, and ongoing COVID-19 clinical trials using zinc.",

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AU - Pal, Amit

AU - Squitti, Rosanna

AU - Picozza, Mario

AU - Pawar, Anil

AU - Rongioletti, Mauro

AU - Dutta, Atanu Kumar

AU - Sahoo, Sibasish

AU - Goswami, Kalyan

AU - Sharma, Praveen

AU - Prasad, Rajendra

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N2 - Coronavirus disease-2019 (COVID-19) pandemic continues to threaten patients, societies, and economic and healthcare systems around the world. Like many other diseases, the host immune system determines the progress of COVID-19 and fatality. Modulation of inflammatory response and cytokine production using immunonutrition is a novel concept that has been applied to other diseases as well. Zinc, one of the anti-inflammatory and antioxidant micronutrient found in food with well-established role in immunity, is currently being used in some clinical trials against COVID-19. This review integrates the contemporary studies of role of zinc in antiviral immunity along with discussing its potential role against COVID-19, and ongoing COVID-19 clinical trials using zinc.

AB - Coronavirus disease-2019 (COVID-19) pandemic continues to threaten patients, societies, and economic and healthcare systems around the world. Like many other diseases, the host immune system determines the progress of COVID-19 and fatality. Modulation of inflammatory response and cytokine production using immunonutrition is a novel concept that has been applied to other diseases as well. Zinc, one of the anti-inflammatory and antioxidant micronutrient found in food with well-established role in immunity, is currently being used in some clinical trials against COVID-19. This review integrates the contemporary studies of role of zinc in antiviral immunity along with discussing its potential role against COVID-19, and ongoing COVID-19 clinical trials using zinc.

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Zinc and COVID-19: Basis of Current Clinical Trials

Abstract

Keywords

ASJC Scopus subject areas

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