TY - JOUR
T1 - Zinc in elderly people
T2 - Effects of zinc supplementation on psychological dimensions in dependence of IL-6 -174 polymorphism: A zincage study
AU - Marcellini, Fiorella
AU - Giuli, Cinzia
AU - Papa, Roberta
AU - Gagliardi, Cristina
AU - Dedoussis, George
AU - Monti, Daniela
AU - Jajte, Jolanta
AU - Giacconi, Robertina
AU - Malavolta, Marco
AU - Mocchegiani, Eugenio
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Zinc is relevant for psychological dimensions, which are altered in zinc deficiency, as in aging. Since zinc deficiency and the beneficial effect of zinc supplementation may be related to genotypes of IL-6 -174 polymorphism, the main goal was to examine psychological dimensions in relationship to plasma zinc and genetic background of IL-6 in healthy elderly subjects, recruited in Italy, Greece, and Poland, before and after zinc supplementation. On the basis of IL-6 -174 polymorphism, significant restoration occurs for PSS, especially in Greece and Poland, less for MMSE and GDS, after zinc supplementation, suggesting zinc is important in reducing stress in elderly people.
AB - Zinc is relevant for psychological dimensions, which are altered in zinc deficiency, as in aging. Since zinc deficiency and the beneficial effect of zinc supplementation may be related to genotypes of IL-6 -174 polymorphism, the main goal was to examine psychological dimensions in relationship to plasma zinc and genetic background of IL-6 in healthy elderly subjects, recruited in Italy, Greece, and Poland, before and after zinc supplementation. On the basis of IL-6 -174 polymorphism, significant restoration occurs for PSS, especially in Greece and Poland, less for MMSE and GDS, after zinc supplementation, suggesting zinc is important in reducing stress in elderly people.
UR - http://www.scopus.com/inward/record.url?scp=42649130366&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42649130366&partnerID=8YFLogxK
U2 - 10.1089/rej.2008.0680
DO - 10.1089/rej.2008.0680
M3 - Article
C2 - 18341424
AN - SCOPUS:42649130366
VL - 11
SP - 479
EP - 483
JO - Rejuvenation Research
JF - Rejuvenation Research
SN - 1549-1684
IS - 2
ER -