Zinc in elderly people: Effects of zinc supplementation on psychological dimensions in dependence of IL-6 -174 polymorphism: A zincage study

Fiorella Marcellini; Cinzia Giuli; Roberta Papa; Cristina Gagliardi; George Dedoussis; Daniela Monti; Jolanta Jajte; Robertina Giacconi; Marco Malavolta; Eugenio Mocchegiani

doi:10.1089/rej.2008.0680

Zinc in elderly people: Effects of zinc supplementation on psychological dimensions in dependence of IL-6 -174 polymorphism: A zincage study

Fiorella Marcellini, Cinzia Giuli, Roberta Papa, Cristina Gagliardi, George Dedoussis, Daniela Monti, Jolanta Jajte, Robertina Giacconi, Marco Malavolta, Eugenio Mocchegiani

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

Zinc is relevant for psychological dimensions, which are altered in zinc deficiency, as in aging. Since zinc deficiency and the beneficial effect of zinc supplementation may be related to genotypes of IL-6 -174 polymorphism, the main goal was to examine psychological dimensions in relationship to plasma zinc and genetic background of IL-6 in healthy elderly subjects, recruited in Italy, Greece, and Poland, before and after zinc supplementation. On the basis of IL-6 -174 polymorphism, significant restoration occurs for PSS, especially in Greece and Poland, less for MMSE and GDS, after zinc supplementation, suggesting zinc is important in reducing stress in elderly people.

Original language	English
Pages (from-to)	479-483
Number of pages	5
Journal	Rejuvenation Research
Volume	11
Issue number	2
DOIs	https://doi.org/10.1089/rej.2008.0680
Publication status	Published - Apr 1 2008

ASJC Scopus subject areas

Ageing

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Zinc in elderly people : Effects of zinc supplementation on psychological dimensions in dependence of IL-6 -174 polymorphism: A zincage study. / Marcellini, Fiorella; Giuli, Cinzia ; Papa, Roberta ; Gagliardi, Cristina; Dedoussis, George; Monti, Daniela; Jajte, Jolanta; Giacconi, Robertina ; Malavolta, Marco; Mocchegiani, Eugenio.

In: Rejuvenation Research, Vol. 11, No. 2, 01.04.2008, p. 479-483.

Research output: Contribution to journal › Article › peer-review

Marcellini, Fiorella ; Giuli, Cinzia ; Papa, Roberta ; Gagliardi, Cristina ; Dedoussis, George ; Monti, Daniela ; Jajte, Jolanta ; Giacconi, Robertina ; Malavolta, Marco ; Mocchegiani, Eugenio. / Zinc in elderly people : Effects of zinc supplementation on psychological dimensions in dependence of IL-6 -174 polymorphism: A zincage study. In: Rejuvenation Research. 2008 ; Vol. 11, No. 2. pp. 479-483.

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AU - Gagliardi, Cristina

AU - Dedoussis, George

AU - Monti, Daniela

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AU - Malavolta, Marco

AU - Mocchegiani, Eugenio

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