Zinc, metallothioneins, longevity: Effect of zinc supplementation on antioxidant response: A zincage study

Eugenio Mocchegiani, Marco Malavolta, Robertina Giacconi, Catia Cipriano, Laura Costarelli, Elisa Muti, Silvia Tesei, Cinzia Giuli, Roberta Papa, Fiorella Marcellini, Erminia Mariani, Lothar Rink, George Herbein, Tamas Fulop, Daniela Monti, Jolanta Jajte, George Dedoussis, Efstathios S. Gonos, Alexander Buerkle, Betrand FriguetPatrizia Mecocci, Marco Colasanti, Csaba Soti, Dawn Mazzatti, Maria Blasco, Richard Aspinall, Graham Pawelec

Research output: Contribution to journalArticlepeer-review

Abstract

Aging is characterized by spontaneous biochemical changes that may predispose to increased susceptibility to diseases. Zinc may remodel these changes leading to healthy aging because zinc improves antioxidant defense via CLU protein and genomic stability via PARP-1 nuclear enzyme and repairs oxidized proteins via Msr A protein. The intracellular zinc homeostasis is regulated by metallothioneins (MT), which are unable in zinc release in aging, causing impaired antioxidant response restored by zinc supplementation. Here, the choice of old subjects for zinc supplementation is discussed in relation to their genetic background of MT and IL-6, because both affect intracellular zinc homeostasis.

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalRejuvenation Research
Volume11
Issue number2
DOIs
Publication statusPublished - Apr 1 2008

ASJC Scopus subject areas

  • Ageing

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