Zinc signalling and subcellular distribution: emerging targets in type 2 diabetes

Eugenio Mocchegiani, Robertina Giacconi, Marco Malavolta

Research output: Contribution to journalArticle

Abstract

A finely tuned subcellular distribution of zinc (Zn), through the coordinated action of Zn transporters (ZnTs) and metallothioneins (MTs), is crucial for optimal cell function. Dysfunctions of these proteins might act as key causative or promoting factors in several chronic pathologies. Evidence of their involvement in the pathogenesis of type 2 diabetes (DM2) is emerging. The association of single nucleotide polymorphisms in genes encoding ZnT-8 and MT with DM2 has drawn attention to the relevance of Zn homeostasis for insulin secretory capacity and responsiveness. Here, we propose that potential mechanisms leading to altered subcellular Zn distribution rather than deficiency might be important in DM2. Increasing knowledge of the mechanisms of Zn homeostasis and signalling should promote the development of targeted interventions with the potential to reduce the burden of disease.

Original languageEnglish
Pages (from-to)419-428
Number of pages10
JournalTrends in Molecular Medicine
Volume14
Issue number10
DOIs
Publication statusPublished - Oct 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

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