Zinc supplementation and plasma lipid peroxides in an elderly population

C. Fortes, N. Agabiti, V. Fano, R. Pacifici, F. Forastiere, F. Virgili, P. Zuccaro, C. A. Perruci, S. Ebrahim

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective: To determine the effect of vitamin A, zinc or both on plasma lipid peroxides in a healthy elderly population. Design: Double-blind randomized controlled trial supplementation of vitamin A and zinc. Setting: Public home for elderly people, in Rome, Italy. Subjects: A total of 178 residents of a Public home for elderly people were evaluated regarding health and nutritional status. 136 gave a written consensus to participate in the trial and were randomized in four groups of treatment. 118 elderly completed the trial. Interventions: Three months supplementation of the following treatments: (1) vitamin A (800 μg retinol palmitate); (2) zinc (25 mg zinc as sulphate); (3) vitamin A and zinc (800 μg retinol palmitate and 25 mg zinc as sulphate); (4) placebo (starch containing capsules). Main outcome measures: Plasma lipid peroxides (TBA-RS) were measured before and after supplementation. Results: Zinc supplementation was associated with a decrease in plasma lipid peroxides (β = -0.19; 95% confidence levels: -0.37, -0.002; p-value = 0.05) after adjusting for sex, smoking habits, baseline plasma lipid peroxides and vitamin A plasma levels. Conclusions: Zinc supplementation decreased plasma lipid peroxides while vitamin A had no effect in this elderly population. Adequate zinc intake or supplementation could play an important role in the prevention and/or modulation of diseases in the elderly people.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalEuropean Journal of Clinical Nutrition
Volume51
Issue number2
Publication statusPublished - Feb 1997

Fingerprint

Lipid Peroxides
peroxides
blood lipids
Zinc
Vitamin A
zinc
vitamin A
Population
Zinc Sulfate
retinyl palmitate
sulfates
Nutritional Status
Starch
Italy
smoking (habit)
Health Status
Habits
Capsules
Consensus
Randomized Controlled Trials

Keywords

  • Elderly
  • Plasma lipid peroxides
  • Randomized clinical trial
  • Vitamin A and zinc supplementation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Fortes, C., Agabiti, N., Fano, V., Pacifici, R., Forastiere, F., Virgili, F., ... Ebrahim, S. (1997). Zinc supplementation and plasma lipid peroxides in an elderly population. European Journal of Clinical Nutrition, 51(2), 97-101.

Zinc supplementation and plasma lipid peroxides in an elderly population. / Fortes, C.; Agabiti, N.; Fano, V.; Pacifici, R.; Forastiere, F.; Virgili, F.; Zuccaro, P.; Perruci, C. A.; Ebrahim, S.

In: European Journal of Clinical Nutrition, Vol. 51, No. 2, 02.1997, p. 97-101.

Research output: Contribution to journalArticle

Fortes, C, Agabiti, N, Fano, V, Pacifici, R, Forastiere, F, Virgili, F, Zuccaro, P, Perruci, CA & Ebrahim, S 1997, 'Zinc supplementation and plasma lipid peroxides in an elderly population', European Journal of Clinical Nutrition, vol. 51, no. 2, pp. 97-101.
Fortes C, Agabiti N, Fano V, Pacifici R, Forastiere F, Virgili F et al. Zinc supplementation and plasma lipid peroxides in an elderly population. European Journal of Clinical Nutrition. 1997 Feb;51(2):97-101.
Fortes, C. ; Agabiti, N. ; Fano, V. ; Pacifici, R. ; Forastiere, F. ; Virgili, F. ; Zuccaro, P. ; Perruci, C. A. ; Ebrahim, S. / Zinc supplementation and plasma lipid peroxides in an elderly population. In: European Journal of Clinical Nutrition. 1997 ; Vol. 51, No. 2. pp. 97-101.
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abstract = "Objective: To determine the effect of vitamin A, zinc or both on plasma lipid peroxides in a healthy elderly population. Design: Double-blind randomized controlled trial supplementation of vitamin A and zinc. Setting: Public home for elderly people, in Rome, Italy. Subjects: A total of 178 residents of a Public home for elderly people were evaluated regarding health and nutritional status. 136 gave a written consensus to participate in the trial and were randomized in four groups of treatment. 118 elderly completed the trial. Interventions: Three months supplementation of the following treatments: (1) vitamin A (800 μg retinol palmitate); (2) zinc (25 mg zinc as sulphate); (3) vitamin A and zinc (800 μg retinol palmitate and 25 mg zinc as sulphate); (4) placebo (starch containing capsules). Main outcome measures: Plasma lipid peroxides (TBA-RS) were measured before and after supplementation. Results: Zinc supplementation was associated with a decrease in plasma lipid peroxides (β = -0.19; 95{\%} confidence levels: -0.37, -0.002; p-value = 0.05) after adjusting for sex, smoking habits, baseline plasma lipid peroxides and vitamin A plasma levels. Conclusions: Zinc supplementation decreased plasma lipid peroxides while vitamin A had no effect in this elderly population. Adequate zinc intake or supplementation could play an important role in the prevention and/or modulation of diseases in the elderly people.",
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