Zinc supplementation and plasma lipid peroxides in an elderly population

C. Fortes, N. Agabiti, V. Fano, R. Pacifici, F. Forastiere, F. Virgili, P. Zuccaro, C. A. Perruci, S. Ebrahim

Research output: Contribution to journalArticlepeer-review


Objective: To determine the effect of vitamin A, zinc or both on plasma lipid peroxides in a healthy elderly population. Design: Double-blind randomized controlled trial supplementation of vitamin A and zinc. Setting: Public home for elderly people, in Rome, Italy. Subjects: A total of 178 residents of a Public home for elderly people were evaluated regarding health and nutritional status. 136 gave a written consensus to participate in the trial and were randomized in four groups of treatment. 118 elderly completed the trial. Interventions: Three months supplementation of the following treatments: (1) vitamin A (800 μg retinol palmitate); (2) zinc (25 mg zinc as sulphate); (3) vitamin A and zinc (800 μg retinol palmitate and 25 mg zinc as sulphate); (4) placebo (starch containing capsules). Main outcome measures: Plasma lipid peroxides (TBA-RS) were measured before and after supplementation. Results: Zinc supplementation was associated with a decrease in plasma lipid peroxides (β = -0.19; 95% confidence levels: -0.37, -0.002; p-value = 0.05) after adjusting for sex, smoking habits, baseline plasma lipid peroxides and vitamin A plasma levels. Conclusions: Zinc supplementation decreased plasma lipid peroxides while vitamin A had no effect in this elderly population. Adequate zinc intake or supplementation could play an important role in the prevention and/or modulation of diseases in the elderly people.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalEuropean Journal of Clinical Nutrition
Issue number2
Publication statusPublished - Feb 1997


  • Elderly
  • Plasma lipid peroxides
  • Randomized clinical trial
  • Vitamin A and zinc supplementation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science


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