Zinc transporter 8 autoantibodies increase the predictive value of islet autoantibodies for function loss of technically successful solitary pancreas transplant

Margherita Occhipinti, Vito Lampasona, Fabio Vistoli, Elena Bazzigaluppi, Marina Scavini, Ugo Boggi, Piero Marchetti, Emanuele Bosi

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Despite the success rate of solitary pancreas transplantation in type 1 diabetes with preserved kidney function has greatly improved in recent years, a residual proportion of failures persists. Methods. With the aim of investigating autoimmunity as an unrecognized cause of graft failure, we measured autoantibodies to glutamic acid decarboxylase (GADA), insulinoma-associated protein 2 (IA-2A) and the recently discovered zinc transporter 8 antigen (ZnT8A) in 25 recipients of technically successful solitary pancreas transplantation. Results. The overall pancreas graft survival was 92%, 88%, and 80% at 2, 4, and 6 years, respectively. Fourteen patients (56%) had one or more autoantibodies before transplantation, with no effect on subsequent pancreas graft outcome. After transplantation, major autoantibody changes (serum conversion from negative to positive, spreading from one to multiple autoantibodies, or titer increase) were observed in 5 of 25 recipients: in four patients, the autoantibody change was followed by the loss of graft function (95% sensitivity, 80% positive predictive value), with a significantly lower graft survival compared with patients without autoantibodies (P

Original languageEnglish
Pages (from-to)674-677
Number of pages4
JournalTransplantation
Volume92
Issue number6
DOIs
Publication statusPublished - Sep 27 2011

Keywords

  • Islet autoantibodies
  • Solitary pancreas transplant
  • Type 1 diabetes
  • ZnT8 autoantibodies

ASJC Scopus subject areas

  • Transplantation

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