Zipeprol is a newly abused antitussive with an opioid spectrum and hallucinogenic effects

Luigi Janiri, Paolo Mannelli, Antonio M. Persico, Silvana Diodato, Enrico Tempesta

Research output: Contribution to journalArticle

Abstract

Zipeprol is a non-opioid cough suppressor agent recently abused in Italy. Clinical reports from 30 street abusers show that the drug in high doses has a definite abuse liability and dependence potential. Many of its effects were identical to those induced by opiates, although specific dysperceptive symptoms were commonly reported by patients. Spontaneous withdrawal symptoms were similar to those of opiates. Withdrawal could be also precipitated by naloxone. It is concluded that zipeprol can induce dependence with a mechanism which may be mediated by some types of opioid receptors.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalDrug and Alcohol Dependence
Volume27
Issue number2
DOIs
Publication statusPublished - 1991

Keywords

  • antitussive
  • dependence
  • withdrawal
  • zipeprol

ASJC Scopus subject areas

  • Medicine(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

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