Zn and Cu alteration in connection with astrocyte metallothionein I/II overexpression in the mouse brain upon physical stress

Mariano Beltramini, Cristina Di Pisa, Pamela Zambenedetti, Werner Wittkowski, Eugenio Mocchegianni, Massimo Musicco, Paolo Zatta

Research output: Contribution to journalArticlepeer-review

Abstract

The distribution of metallothioneins I/II in the mouse brain and their specific area distribution upon physical stress were studied. To induce physical stress, groups of mice were subjected to total darkness for different periods (2 weeks, 1 month, and 2 months). The concentration of metallothioneins, evaluated by immunohistochemistry, as well as area-specific protein expression, were found in the following quantitative order: corpus striatum, cerebellum, mesencephalon, hippocampus with fornix, parts of thalamus, and pons. All other brain areas were marginally affected, or even unaffected, in terms of immunopositive metallothionein reaction. Metallothionein I/II expression was compared with the immunopositivity of glial fibrillary acidic protein (GFAP). It is noteworthy that metallothioneins and GFAP are expressed in different types of astrocytes.

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalGLIA
Volume47
Issue number1
DOIs
Publication statusPublished - Jul 2004

Keywords

  • Astrocytes
  • Brain
  • Copper
  • Glial fibrillary acid protein
  • Metallothioneins
  • Physical stress
  • Zinc

ASJC Scopus subject areas

  • Immunology

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