Zoledronic acid induces a significant decrease of circulating endothelial cells and circulating endothelial precursor cells in the early prostate cancer neoadjuvant setting

Daniele Santini, Alice Zoccoli, Chiara Gregorj, Melania Di Cerbo, Michele Iuliani, Francesco Pantano, Rita Zamarchi, Federico Sergi, Gerardo Flammia, Maurizio Buscarini, Sergio Rizzo, Giuseppe Cicero, Antonio Russo, Bruno Vincenzi, Giuseppe Avvisati, Giuseppe Tonini

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Published data demonstrated that zoledronic acid (ZOL) exhibits antiangiogenetic effects. A promising tool for monitoring antiangiogenic therapies is the measurement of circulating endothelial cells (CECs) and circulating endothelial precursor cells (CEPs) in the peripheral blood of patients. Our aim was to investigate the effects of ZOL on levels of CECs and CEPs in localized prostate cancer. Methods: Ten consecutive patients with a histologic diagnosis of low-risk prostate adenocarcinoma were enrolled and received an intravenous infusion of ZOL at baseline (T0), 28 days (T28) and 56 days (T56). Blood samples were collected at the following times: T0 (before the first infusion of ZOL), T3 (72 h after the first dose), T28, T56 (both just before the ZOL infusion) and T84 (28 days after the last infusion of ZOL) and CEC/CEP levels were directly quantified by flow cytometry at all these time points. Results: Our analyses highlighted a significant reduction of mean percentage of CECs and CEPs after initiation of ZOL treatment [p = 0.014 (at day 3) and p = 0.012 (at day 84), respectively]. Conclusion: These preliminary results demonstrate that ZOL could exert an antiangiogenic effect in early prostate cancer through CEP and CEC modulation.

Original languageEnglish
Pages (from-to)342-347
Number of pages6
JournalOncology
Volume85
Issue number6
DOIs
Publication statusPublished - Dec 2013

Keywords

  • Angiogenesis
  • Circulating endothelial cells
  • Circulating endothelial precursor cells
  • Prostate cancer
  • Zoledronic acid

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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