ZPLD1 gene is disrupted in a patient with balanced translocation that exhibits cerebral cavernous malformations

F. Gianfrancesco, T. Esposito, S. Penco, V. Maglione, C. L. Liquori, M. C. Patrosso, O. Zuffardi, A. Ciccodicola, D. A. Marchuk, F. Squitieri

Research output: Contribution to journalArticle

Abstract

The past few years have seen rapid advances in our understanding of the genetics and molecular biology of cerebral cavernous malformations (CCM) with the identification of the CCM1, CCM2, and CCM3 genes. Recently, we have recruited a patient with an X/3 balanced translocation that exhibits CCM. By fluorescent in situ hybridization analysis, sequence analysis tools and database mining procedures, we refined the critical region to an interval of 200-kb and identified the interrupted ZPLD1 gene. We detected that the mRNA expression level of ZPLD1 gene is consistently decreased 2.5-fold versus control (P=0.0006) with allelic loss of gene expression suggesting that this protein may be part of the complex signaling pathway implicated in CCM formation.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalNeuroscience
Volume155
Issue number2
DOIs
Publication statusPublished - Aug 13 2008

Keywords

  • cerebral cavernous malformations
  • KRIT1
  • MGC4607
  • PDCD10
  • ZPLD1

ASJC Scopus subject areas

  • Neuroscience(all)

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    Gianfrancesco, F., Esposito, T., Penco, S., Maglione, V., Liquori, C. L., Patrosso, M. C., Zuffardi, O., Ciccodicola, A., Marchuk, D. A., & Squitieri, F. (2008). ZPLD1 gene is disrupted in a patient with balanced translocation that exhibits cerebral cavernous malformations. Neuroscience, 155(2), 345-349. https://doi.org/10.1016/j.neuroscience.2008.05.030